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A modulation of the anaphylactic basophil histamine release by selective H2 histamine agonists

  • Histamine and Immunology
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Abstract

Two selective H2-histamine agonists, dimaprit and impromidine, have been tested for their action on histamine release from human basophils and rat mast cells.

IgE-mediated basophil histamine release was inhibited by stimulation of histamine H2-receptors. However, differences between the actions of both dimaprit and impromidine were noticed. Both impromidine and dimaprit had no specific effect on 48/80-induced histamine release from rat mast cells, although the latter in higher concentrations either slightly increased spontaneous histamine release or non-specifically inhibited compound 48/80-induced release.

The results are consistent with the view that activation of adenylate cyclase via H2-histamine receptors might be an important regulatory mechanism of histamine release from human basophils but not from rat mast cells.

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Authors and Affiliations

  1. Department of Biogenic Amines, Polish Academy of Sciences, 60 Narutowicza Str., 90-136, Łódź, Poland

    Wacław Kazimierczak, Krystyna Szczepaniak & Katarzyna Bańkowska

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  1. Wacław Kazimierczak
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  2. Krystyna Szczepaniak
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  3. Katarzyna Bańkowska
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Kazimierczak, W., Szczepaniak, K. & Bańkowska, K. A modulation of the anaphylactic basophil histamine release by selective H2 histamine agonists. Agents and Actions 11, 96–98 (1981). https://doi.org/10.1007/BF01991468

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  • DOI: https://doi.org/10.1007/BF01991468

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