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Effect of PAF on erythrocyte membrane heterogeneity: A fluorescence study

  • Inflammation and Immunomodulation
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Abstract

The effect of platelet activating factor, PAF, on the erythrocyte membrane heterogeneity was investigated by measuring the steady-state fluorescence anisotropy and fluorescence decay of 1-(4-trimethylammoniumphenyl)-6-phenyl-1,3,5-hexatriene (TMA-DPH) incorporated in hemoglobin-free erythrocyte membranes. PAF induced a significant increase of the lipid order in the exterior part of the membrane and a decrease in membrane heterogeneity. These results indicate that PAF may cause changes in the physico-chemical structure of the erythrocyte membrane.

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Authors and Affiliations

  1. Department of Pediatrics, University of Ancona, via corridoni 11, 60123, Ancona, Italy

    A. Kantar & P. L. Giorgi

  2. Department of Biochemistry, University of Ancona, via corridoni 11, 60123, Ancona, Italy

    G. Curatola & R. Fiorini

Authors
  1. A. Kantar
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  2. P. L. Giorgi
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  3. G. Curatola
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  4. R. Fiorini
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Kantar, A., Giorgi, P.L., Curatola, G. et al. Effect of PAF on erythrocyte membrane heterogeneity: A fluorescence study. Agents and Actions 32, 347–350 (1991). https://doi.org/10.1007/BF01980897

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  • DOI: https://doi.org/10.1007/BF01980897

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