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Neutropenia induced by platelet-activating factor (PAF-acether) released from neutrophils: The inhibitory effect of prostacyclin (PGI2)

  • Proceedings of the 3rd European Workshop on Inflammation, Paris, 2–3 March 1981
  • Phospholipase: Role in Cellular Activation
  • Published:
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Abstract

Soluble and phagocytic stimuli released PAF-acether from PMN leucocytes, as determined by chromatography and bioassay by platelet aggregation. The same material caused aggregation of human and rabbit PMN leucocytesin vitro which was inhibited by ETYA and PGI2. PGI2 also inhibited PAF-acether release by PMN leucocytes and,in vivo, PGI2 abolished not only PAF-acether-induced, but also immune complex or C5a-induced thrombocytopenia and neutropenia in rabbits. These data suggest that PAF-acether may be involved in activation of both platelets and PMN leucocytesin vivo.

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Authors and Affiliations

  1. Laboratorio di Immunopatologia, Cattedra di Nefrologia, Osp. S.G. Battista, Turin, Italy

    Giovanni Camussi, Ciro Tetta, Giuseppe Segoloni, M. Chiara Deregibus & Federico Bussolino

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  1. Giovanni Camussi
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  2. Ciro Tetta
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  3. Giuseppe Segoloni
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  4. M. Chiara Deregibus
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  5. Federico Bussolino
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Camussi, G., Tetta, C., Segoloni, G. et al. Neutropenia induced by platelet-activating factor (PAF-acether) released from neutrophils: The inhibitory effect of prostacyclin (PGI2). Agents and Actions 11, 550–553 (1981). https://doi.org/10.1007/BF01978735

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