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In vitro metabolism of cadaverine in the pregnant rat

  • Histamine Metabolism
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Abstract

Thein vitro metabolism of14C-cadaverine by diamine oxidase was investigated in various tissues of pregnant and non-pregnant rats. The metabolites formed were: Δ1-piperideine, δ-aminovaleric acid, carbon dioxide and some unidentified compound(s). In most of the tissues investigated Δ1-piperideine was the predominant metabolite, but considerable amounts of δ-aminovaleric acid and the unidentified compound(s) were also formed. The oxidative products of cadaverine might be of importance in various physiological and pathophysiological connections associated with elevated diamine oxidase levels.

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References

  1. A.-Ch. Andersson, S. Henningsson andE. Rosengren,Increased formation of diamines and polyamines in the pregnant rat. J. Physiol., Lond.285, 311–324 (1978).

    Google Scholar 

  2. Y. Kobayashi,Plasma diamine oxidase titres of normal and pregnant rats, Nature, Lond.203, 146–147 (1964).

    Google Scholar 

  3. M. Roberts andJ.M. Robson The histaminase content of the rat uterus, and its relation to the decidua. J. Physiol., Lond.119, 286–291 (1953).

    Google Scholar 

  4. K.S. Kim andM.E. Harris, Mechanism of increased diamine oxidase activity in pregnancy and the possible roles of diamine oxidase in the uterus and the ovary. InHistamine int. Congr. Physiol. Sci. pp. 312–326 (Ed.Cz. Maslinski) 1973.

  5. C. Schöpf, A. Komzak, F. Braun, E. Jacobi, M.-L. Bormuth, M. Bullnheimer andI. Hagel, Über die Polymeren des Δ1-Piperideine, Justus Liebigs Annln Chem.559, 1–42 (1948).

    Google Scholar 

  6. T. Okuyama andY. Kobayashi,Determination of diamine oxidase activity by liquid scintillation counting, Archs Biochem. Biophys.95, 242–250 (1961).

    Article  Google Scholar 

  7. C. de Marco andB. Mondovi,Identification of δ-aminovalerianic acid in the urine of rats injected with cadaverine, Ital. J. Biochem.9, 226–232 (1960).

    Google Scholar 

  8. A.-Ch. Henningsson andS. Henningsson,Metabolism of cadaverine in vivo of the pregnant rat, to be published.

  9. R.W. Schayer, R.L. Smiley andJ. Kennedy,Diamine oxidase and cadaverine metabolism, J. biol. Chem.206, 461–464 (1954).

    PubMed  Google Scholar 

  10. A.-Ch. Andersson, S. Hennningsson, L. Persson andE. Rosengren,Aspects on diamine oxidase activity and its determination, Acta physiol. scand.102, 159–166 (1978).

    PubMed  Google Scholar 

  11. A.-Ch. Andersson andS. Henningsson,Metabolism of putrescine in the pregnant rat, Acta physiol. scand.113, 523–532 (1981).

    PubMed  Google Scholar 

  12. S. Henningsson,Automated liquid chromatography in research on histamine metabolism, Agents and Actions8, 392–393 (1978).

    Article  Google Scholar 

  13. A.-Ch. Andersson, S. Henningsson andE. Rosengren,Formation of cadaverine in the pregnant rat, Acta physiol. scand.105, 508–512 (1979).

    PubMed  Google Scholar 

  14. C.F. Baxter, The nature of γ-aminobutyric acid. InHandbook of Neurochemistry, vol. 3, pp. 289–353 (Ed.Lajtha). Plenum Press, New York, London 1970.

    Google Scholar 

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Henningsson, AC., Henningsson, S. In vitro metabolism of cadaverine in the pregnant rat. Agents and Actions 13, 262–264 (1983). https://doi.org/10.1007/BF01967348

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  • DOI: https://doi.org/10.1007/BF01967348

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