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Effect of salmon calcitonin on the infiltration of T lymphocytes in a synovium-like membrane of a rat inflammatory model

  • Inflammation and Immunomodulation
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Abstract

The effect of salmon calcitonin (SCT) on the number of T lymphocytes accumulating in air pouch lining membranes produced on the back of Wistar rats was studied. SCT was given from day 0 through day seven following the air cavitation by daily injections of 2.5–20 μg/kg directly into the air cavity. Compared with saline controls, treatment with SCT caused a clear reduction in percentage of T lymphocytes, T helper cells and T non-helper subset in the synovial-like air pouch lining as revealed by FITC-labeled monoclonal antibodies and quantified by flow cytophotometric measurements. This effect may be due to a reduction in local vascular permeability caused by SCT.

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Authors and Affiliations

  1. Preclinical Research Division, Sandoz Ltd., CH-4002, Basel, Switzerland

    A. Grieder

  2. Rheumaklinik und Institut, Universitätsspital Zürich, Gloriastrasse 25, CH-8091, Zürich, Switzerland

    M. Felder

  3. Pharmaceutical Institute, University of Basel, Totengässlein, CH-4051, Basel, Switzerland

    W. Schaffner

Authors
  1. A. Grieder
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  2. M. Felder
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  3. W. Schaffner
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Grieder, A., Felder, M. & Schaffner, W. Effect of salmon calcitonin on the infiltration of T lymphocytes in a synovium-like membrane of a rat inflammatory model. Agents and Actions 29, 308–314 (1990). https://doi.org/10.1007/BF01966462

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  • DOI: https://doi.org/10.1007/BF01966462

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