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Spontaneous osteo-arthritis of the knee-joint in C57BL mice receiving chronic oral treatment with NSAID's or prednisone

  • Inflammation and Immunomodulation
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Abstract

In a statistically planned study based on quantitative radiography, treatment for 25–26 weeks with the 2 NSAIDs, diclofenac sodium, or indomethacin (both 0.5 and 1.5 mg/kg p.o. daily), or prednisone (6 mg/kg p.o.) had no influence on the progression of spontaneous osteo-arthritis of the knee-joint of the C57BL mouse, by comparison with placebo-treated controls.

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Authors and Affiliations

  1. Pharmaceuticals Division, Ciba-Geigy Limited, K-125.5.16, CH-4002, Basle, Switzerland

    A. Pataki, H. P. Graf & E. Witzemann

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  1. A. Pataki
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  2. H. P. Graf
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  3. E. Witzemann
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Pataki, A., Graf, H.P. & Witzemann, E. Spontaneous osteo-arthritis of the knee-joint in C57BL mice receiving chronic oral treatment with NSAID's or prednisone. Agents and Actions 29, 210–217 (1990). https://doi.org/10.1007/BF01966449

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  • DOI: https://doi.org/10.1007/BF01966449

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