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Sustained release of a corticosteroid using polymeric implants

  • Immunosuppression and Inflammation
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Abstract

An effective sustained release method of drug administration, using methylprednisolone incorporated into acrylic bone cement, has been developed. The effect of this form of treatment on peripheral blood leukocytes, lymphoid tissue weight and the inflammatory response has been evaluated. This mode of methylprednisolone administration was compared with conventional systemic therapy and was found to produce rapid and prolonged pharmacological effects at very low plasma levels of drug. A dose response relationship was established and we determined that, for a given quantity of drug, the level and duration of suppression was greater using sustained release therapy. The inflammatory response was also depressed using this mode of administration. These results, coupled with the commercial availability and existing clinical approval of SIMPLEX P bone cement, suggest that further development may lead to useful clinical protocols.

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Abbreviations

BC:

bone cement

MP:

methylprednisolone

PMN:

polymorphonuclear leukocyte

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Authors and Affiliations

  1. Department of Medicine, Auckland Hospital, Park Road, Auckland, New Zealand

    S. Cawley, D. J. Ormrod & T. E. Miller

  2. Department of Pharmacology, School of Medicine, University of Auckland, Auckland, New Zealand

    J. W. Paxton

Authors
  1. S. Cawley
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  2. D. J. Ormrod
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  3. J. W. Paxton
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  4. T. E. Miller
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Additional information

This study was supported by a grant from the Medical Research Council of New Zealand.

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Cawley, S., Ormrod, D.J., Paxton, J.W. et al. Sustained release of a corticosteroid using polymeric implants. Agents and Actions 19, 233–243 (1986). https://doi.org/10.1007/BF01966211

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  • DOI: https://doi.org/10.1007/BF01966211

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