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Mechanisms of beta-lactam resistance inHaemophilus influenzae

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Abstract

Haemophilus influenzae has become increasingly resistant to beta-lactam antibiotics. Three major mechanisms, both enzymatic and non-enzymatic, are involved. Enzymatic resistance is mainly due to production of a TEM-1 plasmid-mediated beta-lactamase, and in some cases to a new enzyme ROB-1. Of the non-enzymatic mechanisms, decreased permeability due to alteration of outer membrane proteins seems to be rare in comparison to decreased affinity of penicillin-binding proteins for beta-lactam antibiotics. Enzymatic resistance is present in about 10–20% of clinical isolates, while non-enzymatic resistance is present only in 2–4%.

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Authors and Affiliations

  1. Laboratoire de Microbiologie Médicale, Hospital Saint-Joseph, 7 rue Pierre Larousse, 75674, Paris Cedex 14, France

    L. Gutmann & J. F. Acar

  2. Laboratoire de Microbiologie Médicale, Université Pierre et Marie Curie, Faculté de Médecine, 15-21 rue de l'Ecole de Médecine, 75270, Paris Cedex 06, France

    L. Gutmann, R. Williamson, E. Collatz & J. F. Acar

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  4. J. F. Acar
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Gutmann, L., Williamson, R., Collatz, E. et al. Mechanisms of beta-lactam resistance inHaemophilus influenzae . Eur. J. Clin. Microbiol. Infect. Dis. 7, 610–615 (1988). https://doi.org/10.1007/BF01964237

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