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First report of chronic meningitis caused byTrichosporon beigelii

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Abstract

Trichosporon beigelii (Trichosporon cutaneum) was identified as the causative agent of chronic meningitis in a 15-year-old boy with acute lymphocytic leukaemia. After a neutropenic episode following cytostatic treatment and itraconazole therapy as prophylaxis, cerebrospinal fluid (CSF) samples yielded growth ofTrichosporon beigelii. Treatment with amphotericin B, flucytosine and high doses of fluconazole was followed by clinical improvement, although CSF pleocytosis remained. The cross-reactivity betweenCryptococcus neoformans andTrichosporon beigelii in a cryptococcal antigen latex test was used as a means of diagnosis in CSF and serum samples.

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References

  1. Rivera R, Cangir A:Trichosporon sepsis and leukemia. Cancer 1975, 36: 1106–1110.

    PubMed  Google Scholar 

  2. Jameson B, Carter RL, Watson JG, Hay RJ: An unexpected fungal infection in a patient with leukemia. Journal of Clinical Pathology 1981, 34: 267–270.

    PubMed  Google Scholar 

  3. Gold JWM, Poston W, Mertelsmann R, Lange M, Kiehn T, Edwards F, Bernard E, Christiansen K, Armstrong D: Systemic infection withTrichosporon cutaneum in a patient with acute leukemia. Cancer 1981, 48: 2163–2167.

    PubMed  Google Scholar 

  4. Hoy J, Hsu KC, Rolston K, Hopfer RL, Luna M, Bodey GP:Trichosporon beigelii infection: a review. Reviews of Infectious Diseases 1986, 8: 959–967.

    PubMed  Google Scholar 

  5. Wolff M, Curran Y, Bure A, Legrand P, Marche C, Regnier B, Drouhet E, Vachon F: Septicémie mortelle àTrichosporon sp. chez 3 malades immunodéprimés. La Presse Médicale 1986, 15: 1201.

    Google Scholar 

  6. Marin J, Chiner E, Franco J, Borras R:Trichosporon beigelii pneumonia in a neutropenic patient. European Journal of Clinical Microbiology and Infectious Diseases 1989, 8: 631–633.

    Google Scholar 

  7. Murray-Leisure KA, Aber RC, Rowley LJ, Applebaum PC, Wisman CB, Pennock JL, Pierce WC: DisseminatedTrichosporon beigelii (cutaneum) infection in an artificial heart recipient. Journal of the American Medical Association 1986, 256: 2995–2998.

    PubMed  Google Scholar 

  8. Reinhart HH, Urbanski DM, Harrington SD, Sobel JD: Prosthetic valve endocarditis caused byTrichosporon beigelii. American Journal of Medicine 1988, 84: 355–358.

    PubMed  Google Scholar 

  9. Haupt HM, Merz WG, Beschorner WE, Vaughan WP, Saral R: Colonization and infection withTrichosporon species in the immunosuppressed host. Journal of Infectious Diseases 1983, 147: 199–203.

    PubMed  Google Scholar 

  10. Matthews RC, Burnie JP, Fox A, Woods M, Tabaqchali S: Immunoblot analysis of the serological response in invasiveTrichosporon beigelii andBlastoschizomyces capitatus infections. Journal of Clinical Microbiology 1986, 23: 395–397.

    PubMed  Google Scholar 

  11. Drutz DJ: Antigen detection in fungal infections. New England Journal of Medicine 1986, 314: 115–117.

    PubMed  Google Scholar 

  12. Swartz MN: Chronic meningitis — many causes to consider. New England Journal of Medicine 1987, 317: 957–959.

    PubMed  Google Scholar 

  13. McManus EJ, Bozdech MJ, Jones JM: Role of latex agglutination test for cryptococcal antigen in diagnosing disseminated infections withTrichosporon beigelii. Journal of Infectious Diseases 1985, 151: 1167–1169.

    PubMed  Google Scholar 

  14. Tucker RM, Williams PL, Arathoon EG, Levine BE, Harstein AI, Hanson LH, Stevens DA: Pharmacokinetics of fluconazole in cerebrospinal fluid and serum in human coccidioidal meningitis. Antimicrobial Agents and Chemotherapy 1988, 32: 369–373.

    PubMed  Google Scholar 

  15. Anaissie EJ, Bodey GP, Rinaldi MG: Emerging fungal pathogens. European Journal of Clinical Microbiology and Infectious Diseases 1989, 8: 323–330.

    Google Scholar 

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Authors and Affiliations

  1. Department of Microbiology, St. Rafael University Hospital, Capucijnenvoer 33, B-3000, Leuven, Belgium

    I. Surmont, L. Marcelis & L. Verbist

  2. Department of Haematology, Gasthuisberg University Hospital, B-3000, Leuven, Belgium

    B. Vergauwen, G. Verhoef & M. Boogaerts

Authors
  1. I. Surmont
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  2. B. Vergauwen
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  3. L. Marcelis
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  4. L. Verbist
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  5. G. Verhoef
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  6. M. Boogaerts
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Surmont, I., Vergauwen, B., Marcelis, L. et al. First report of chronic meningitis caused byTrichosporon beigelii . Eur. J. Clin. Microbiol. Infect. Dis. 9, 226–229 (1990). https://doi.org/10.1007/BF01963845

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  • DOI: https://doi.org/10.1007/BF01963845

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