Summary
Adenylate cyclase activity in rat striatum decreased post mortem. Half-lives were about 2.7 h at 22°C, 72 h at 4°C. Differences in stability after death of adenylate cyclase in human brain and rat striatum, and possible heterogenity of the enzyme, are briefly discussed.
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References
R. Fumagalli, V. Bernareggi, F. Berti and M. Trabucchi, Life Sci.10, 1111 (1971).
T. Kodama, Y. Matsukado and H. Shimizu, Brain Res.50, 135 (1973).
R. H. Williams S. A. Little and J. W. Ensinck, Am. J. med. Sci.258, 190 (1969).
Y. C. Clément-Cormier, J. W. Kebabian, G. L. Petzold and P. Greengard, Proc. nat. Acad. Sci.71, 1113 (1974).
A. G. Gilman, Proc. nat. Acad. Sci.67, 305 (1970).
W. H. Vogel, V. Orfei and B. Century, J. Pharmac. exp. Ther.165, 196 (1969).
I. B. Black and S. C. Green, Archs Neurol.32, 47 (1975).
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We thank Miss Karin Eckert for excellent technical assistance.
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Witte, P., Matthaei, H. Post mortem changes in adenylate cyclase activity in rat brain striatum. Experientia 35, 1421–1422 (1979). https://doi.org/10.1007/BF01962759
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DOI: https://doi.org/10.1007/BF01962759