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Age-related response of citrate synthase to hydrocortisone in the liver and brain of male rats

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Summary

The activity of citrate synthase of the liver and brain of rats shows a gradual increase as a function of age. Adrenalectomy causes no significant change in the activity of citrate synthase in either of these tissues in young, adult or old rats. Administration of hydrocortisone to adrenalectomized rats depresses the activity of this enzyme maximally in the liver and brain of young rats. Administration of actinomycin D tends to normalize, the depressed level of this enzyme.

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Author notes

  1. R. Sharma

    Present address: Department of Life Sciences, Manipur University, 795003, Canchipur, Imphal, India

Authors and Affiliations

  1. Biochemistry Division, Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, 221005, Varanasi, India

    R. Sharma & S. K. Patnaik

Authors
  1. R. Sharma
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  2. S. K. Patnaik
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Additional information

Acknowledgments. The authors are indebted to Professor M.S. Kanungo of the Department of Zoology of Banaras Hindu University for helpful advice and facilities. A part of this project was presented at the 12th International Congress of Biochemistry, Australia, 1982.

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Sharma, R., Patnaik, S.K. Age-related response of citrate synthase to hydrocortisone in the liver and brain of male rats. Experientia 40, 97–98 (1984). https://doi.org/10.1007/BF01959123

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