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Biological properties of synthetic Ser4-Arg8-oxytocin (Ile3-Ser4-Arginine vasopressin): Role of the residue No. 4 in the hormone-pressor receptor interaction

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Résumé

Les propriétés pharmacologiques de la Ser4-Arg8-ocytocine (Ser4-vasotocine) synthétique ont été étudiées. La substitution en position 4 de la glutamine par la sérine diminue considérablement l'activité pressique de la vasotocine, ce qui montre l'importance de cette position dans les interactions entre les hormones neurohypophysaires et le récepteur vasopressique.

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Authors and Affiliations

  1. Laboratoire de Chimie Biologique, Université de Paris VI, 96, Boulevard Raspail, F-75, Paris 6e, France

    Jacoueline Chauvet, Marie-Thérèse Chauvet & R. Acher

Authors
  1. Jacoueline Chauvet
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  2. Marie-Thérèse Chauvet
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  3. R. Acher
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Additional information

The authors are indebted to Dr.Albert Jöhl (Ciba-Geigy Laboratories) for a sample of synthetic Ser4-Arg8-oxytocin. They thank Mrs.Christine Gaullier for ther skilled technical assistance.

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Chauvet, J., Chauvet, MT. & Acher, R. Biological properties of synthetic Ser4-Arg8-oxytocin (Ile3-Ser4-Arginine vasopressin): Role of the residue No. 4 in the hormone-pressor receptor interaction. Experientia 28, 1493–1495 (1972). https://doi.org/10.1007/BF01957875

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  • DOI: https://doi.org/10.1007/BF01957875

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