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α-Particle track autoradiography for localization of a211At-astatinated drug

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Summary

A potential endoradiotherapeutic drug, 6-211At-astato-2-methyl-1,4-naphthoquinol bis (diphosphate salt), incorporating the α-emitting radio-halogen astatine-211 of half-life 7.2 h, is shown to be valuable for localization studies by means of α-particle track autoradiography in malignant and normal cells and tissues in the mouse with transplanted adenocarcinoma of the rectum.

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Authors and Affiliations

  1. School of Clinical Medicine, Research Laboratories, Radiotherapeutic Centre, Addenbrooke's Hospital, University of Cambridge, Hills Road, CB2 2QQ, Cambridge, UK

    J. S. Mitchell, I. Brown & R. N. Carpenter

Authors
  1. J. S. Mitchell
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  2. I. Brown
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  3. R. N. Carpenter
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Additional information

Beit Memorial Fellow for Medical Research.

Acknowledgments. We are grateful to Prof. J. Walker, Dr P. Fowles and the staff of the Radiation Centre, Birmingham University, and also for the co-operation of Dr A.T.M. Vaughan, Department of Immunology, The Medical School, Birmingham, to Dr L.M. Franks of the Imperial Cancer Research Fund, Lincoln's Inn Fields, London, for the supply of mouse tumors, and to Mr L.F.H. Beard and his staff of the Department of Medical Illustration and Photography, Addenbrooke's Hospital, Hills Road, Cambridge.

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Mitchell, J.S., Brown, I. & Carpenter, R.N. α-Particle track autoradiography for localization of a211At-astatinated drug. Experientia 39, 337–339 (1983). https://doi.org/10.1007/BF01955337

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