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Elevated kidney glucosyltransferase activity in genetic prediabetic mice

  • Specialia Chimica, Biochimica
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Summary

Glucosyltransferase activity in the renal cortex of genetic diabetic KK mice was significantly increased at 40 days of age when compared to that of Swiss albino and F1 hybrid mice. This increase in enzyme activity in the absence of glucose intolerance can be regarded as an earlier genetic marker for the diagnosis of diabetic microangiopathy.

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Authors and Affiliations

  1. Department of Medicine, Diabetes and Metabolism Division, New York Medical College, 1249 Fith Avenue, 10029, New York, N. Y., USA

    A. S. Reddi, W. Oppermann, M. P. Reddy, C. A. Velasco & R. A. Camerini-Davalos

Authors
  1. A. S. Reddi
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  2. W. Oppermann
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  3. M. P. Reddy
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  4. C. A. Velasco
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  5. R. A. Camerini-Davalos
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Additional information

Acknowledgments. This research was supported in part by the General Research Support Grant No. RR-05398 from the General Research Support Branch, Division of Research Resources, National Institutes of Health, National Institutes of Health Training Grant No. 5-T01-AM-05617-06, Hope for Diabetics Foundation, Inc., and Pfizer Research Laboratories. Dr.R. A. Camerini-Davalos was a Career Scientist of the Health Research Council of the City of New York, and Drs.A. S. Reddi andC.A. Velasco were N. I. H. Trainees in Diabetes Mellitus during part of this study.

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Reddi, A.S., Oppermann, W., Reddy, M.P. et al. Elevated kidney glucosyltransferase activity in genetic prediabetic mice. Experientia 32, 1237–1238 (1976). https://doi.org/10.1007/BF01953068

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  • DOI: https://doi.org/10.1007/BF01953068

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