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Induction of hyperlipidemia by human thyroid stimulating hormone immunization in rabbits

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Summary

In our study we are able to demonstrate that with TSH booster and bleeding animals 10–20 days post immunization, when rabbits have increased in antibody titer, there is an increase in cholesterol and triglyceride. These findings are suggestive that most probably we are rendering these rabbits hypothyroid.

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Authors and Affiliations

  1. Metabolism Division and Lipid Research Division, Department of Medicine, University of Cincinnati Medical Center, 45267, Cincinnati, Ohio, USA

    L. S. Srivastava, M. Kashyap, Gladys Perisutti & Ch. -Y. Chen

Authors
  1. L. S. Srivastava
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  2. M. Kashyap
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  3. Gladys Perisutti
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  4. Ch. -Y. Chen
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Additional information

Acknowledgments. The authors are indebted to Miss J. Meister for her skillful technical help. We are also indebted to the National Institute of Arthritis, Metabolism, and Digestive Diseases for Human Thyroid Stimulating Hormone for iodination.

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Srivastava, L.S., Kashyap, M., Perisutti, G. et al. Induction of hyperlipidemia by human thyroid stimulating hormone immunization in rabbits. Experientia 33, 593–595 (1977). https://doi.org/10.1007/BF01946516

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  • DOI: https://doi.org/10.1007/BF01946516

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