Summary
Pancreatic islets were isolated from young (100 g) and adult (390 g), normal and vitamin D deficient male Sprague-Dawley rats. The release of insulin from leucine-stimulated or glucose-stimulated islet was not altered by vitamin D deficiency. The in vitro addition of either 25-hydroxy-or 1,25-dihydroxyvitamin-D had no effect on insulin release from either normal or vitamin D deficient islets. We conclude that the earlier report (Normal et al., Science209 (1980) 823–825) on vitamin D deficiency depressing insulin secretion from the perfused pancreas must be related to the vitamin's effect on insulin synthesis and not the islet's release of insulin.
References
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Chan, J.C.M., Rogers, K.S. Lack of influence of vitamin D deficiency on insulin release from the isolated pancreatic islets of rats. Experientia 42, 1253–1254 (1986). https://doi.org/10.1007/BF01946410
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DOI: https://doi.org/10.1007/BF01946410