Skip to main content
SpringerLink
Log in

Die Wirkung von Silymarin-N-methylglucamin-Salz auf den mikrosomalen Gehalt von Cytochrom P450 der Rattenleber bei akuter Thioacetamidintoxikation

  • Pharmacologica
  • Published:
Experientia Aims and scope Submit manuscript

Summary

24 h after Thioacetamide application (300 mg/kg body weight) on rats, microsomale Cytochrome P450 content is diminished about 40%. Prophylactic i.p. application of 400 mg Silymarine-N-methylglucamine salt, dissolved in 4% Polyvinylpyrrolidone solution, given 1 h before application of Thioacetamide. counteracts this diminution.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  1. H. Schriewer, R. Badde, G. Roth undH. M. Rauen, Arzneimittel-Forsch.23, 160 (1973).

    Google Scholar 

  2. H. Schriewer, J. Lohmann undH. M. Rauen, in Vorbereitung.

  3. E. A. Barker undE. A. Smuckler, Molec. Pharmac.8, 318 (1972).

    CAS  Google Scholar 

  4. N. Hent, Experientia27, 293 (1971).

    Article  Google Scholar 

  5. H. Gallenkamp, D. Brachtel undE. Richter, Acta hepato gastroenterol.21, 101 (1974).

    CAS  Google Scholar 

  6. J. L. Glenn undW. Austin, Biochim. biophys. Acta231, 153 (1971).

    Article  CAS  Google Scholar 

  7. B. Schoene, R. A. Fleischmann, H. Remmer undH. F. v. Oldershausen, Eur. J. clin. Pharmac.4, 65 (1972).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Abteilung für Experimentelle Zellforshung, Physiologisch-Chemisches Institut der Westfälischen Wilhelms-Universität, Waldeyersr 15, D-44, Münster/Westfalen, BRD

    J. Lohmann, H. Schriewer & H. M. Rauen

Authors
  1. J. Lohmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Schriewer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. M. Rauen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lohmann, J., Schriewer, H. & Rauen, H.M. Die Wirkung von Silymarin-N-methylglucamin-Salz auf den mikrosomalen Gehalt von Cytochrom P450 der Rattenleber bei akuter Thioacetamidintoxikation. Experientia 30, 1317–1318 (1974). https://doi.org/10.1007/BF01945206

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01945206

Search

Navigation