Summary
24 h after Thioacetamide application (300 mg/kg body weight) on rats, microsomale Cytochrome P450 content is diminished about 40%. Prophylactic i.p. application of 400 mg Silymarine-N-methylglucamine salt, dissolved in 4% Polyvinylpyrrolidone solution, given 1 h before application of Thioacetamide. counteracts this diminution.
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Lohmann, J., Schriewer, H. & Rauen, H.M. Die Wirkung von Silymarin-N-methylglucamin-Salz auf den mikrosomalen Gehalt von Cytochrom P450 der Rattenleber bei akuter Thioacetamidintoxikation. Experientia 30, 1317–1318 (1974). https://doi.org/10.1007/BF01945206
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DOI: https://doi.org/10.1007/BF01945206