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Lack of platelet factor-3 activation after incubation of platelet-rich plasma with kaolin in the rat

  • Haematologica, Immunologica
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Summary

Stypven times, measured in rat platelet-rich plasma (P. R. P.) after incubation with kaolin, did not shorten as incubation proceeded, thus reflecting the lack of development of platelet factor-3 (PF3) availability in this test system. Repeated freezing and thawing of P. R. P. or aggregation with collagen did result in PF-3 availability. Aggregation and PF-3 availability were inhibited by the compound VK774. These findings add another aspect to the list of species differences in platelet function.

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Author information

Authors and Affiliations

  1. Laboratory for Thrombosis Research, Janssen Pharmaceutica, Turnhoutsebaan 30, B-2340, Beerse, Belgium

    F. de Clerck, J. Goossens & M. Beerens

Authors
  1. F. de Clerck
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  2. J. Goossens
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  3. M. Beerens
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Additional information

This study was partly supported by a grant from I. W. O. N. L.

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de Clerck, F., Goossens, J. & Beerens, M. Lack of platelet factor-3 activation after incubation of platelet-rich plasma with kaolin in the rat. Experientia 32, 1602–1603 (1976). https://doi.org/10.1007/BF01924476

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  • DOI: https://doi.org/10.1007/BF01924476

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