Abstract
Intraperitoneal administration of tuftsin-M [Thr−Lys−Pro−Arg−NH−(CH2)2−NH−CO−C15H31] to Balb/C mice has been shown to induce a respiratory burst in the peritoneal exudate cells. The macrophages exhibited enhanced levels of O2 −, H2O2, NADPH oxidase and myeloperoxidase, but the activities of superoxide dismutase, catalase and glutathione peroxidase remained virtually unchanged. The magnitude of the oxidative burst depended directly on the dose of tuftsin-M; higher activity was observed at higher doses of the peptide. Tuftsin-M enhanced the generation of both O −2 and H2O2 under in vitro conditions, as did phorbol myristate acetate. These results suggest that tuftsin-M could enhance non-specific defence against infections by activating the macrophages.
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Singh, S.P., Chhabra, R. & Srivastava, V.M.L. Respiratory burst in peritoneal exudate cells in response to a modified tuftsin. Experientia 48, 994–996 (1992). https://doi.org/10.1007/BF01919150
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DOI: https://doi.org/10.1007/BF01919150