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Sodium ditiocarb as adjuvant immunotherapy for high risk breast cancer: A randomized study

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Biotherapy

Abstract

Sixty-four patients with non metastatic high risk breast cancer were randomized in a double blind trial of adjuvant immunotherapy with sodium ditiocarb (DDC) versus placebo. All patients underwent prior surgery (mammectomy according to Patey) then adjuvant FAC chemotherapy +/- DDC. With a median follow-up of 5 years we observed 6 relapses and 5 deaths in DDC group; 13 relapses and 12 deaths in control group. At 6 years, overall survival is 81% in DDC group versus 55%. Disease free survival (DFS) is 76% in DDC group versus 55%. DDC associated to chemotherapy and locoregional treatment can improve survival and probably DFS in this high risk breast cancer subgroup.

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Abbreviations

DDC:

sodium ditiocarb

DFS:

disease free survival

OS:

overall survival

N:

node

FAC:

5 Fluorouracil, Adrianycin, Cyclopho-pharmide

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Authors and Affiliations

  1. Service Onco-Hématologie, CHU de Hautepierre, 67098, Strasbourg Cedex, France

    P. Dufour, J. -M. Lang, C. Giron, B. Duclos & F. Oberling

  2. Centre de Radiologie, 23, rue du 22-Novembre, 67000, Strasbourg, France

    P. Haehnel

  3. Service de Chirugie digestive, CHU de Hautepierre, 67098, Strasbourg Cedex, France

    D. Jaeck

  4. Centre Paul Strauss, Place de l'Hopital, 67000, Strasbourg, France

    J. -M. Jung

Authors
  1. P. Dufour
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  2. J. -M. Lang
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  3. C. Giron
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  4. B. Duclos
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  5. P. Haehnel
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  6. D. Jaeck
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  7. J. -M. Jung
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  8. F. Oberling
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Dufour, P., Lang, J.M., Giron, C. et al. Sodium ditiocarb as adjuvant immunotherapy for high risk breast cancer: A randomized study. Biotherapy 6, 9–12 (1993). https://doi.org/10.1007/BF01877380

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  • DOI: https://doi.org/10.1007/BF01877380

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