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Uptake of sorbitol by chick embryo heart cells at various stages of development

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Summary

Sorbitol enters chick embryo heart cells from five days of development on. The rate of sorbitol entry becomes slower as development proceeds and the data suggest this is principally due to an increase in the apparentK m of transport, theV max remaining relatively constant. The uptake of sorbitol displays saturation kinetics and is believed on this ground to be carrier-mediated. Sorbitol does not appear to be actively transported since it is not concentrated against a gradient and its uptake is not inhibited by iodoacetate or 2,4-dinitrophenol. Sorbitol does not appear to be taken up via the glucose transport system since uptake is not stimulated by insulin or inhibited by glucose or phloretin.

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Authors and Affiliations

  1. Department of Physiology, University of Virginia School of Medicine, 22901, Charlottesville, Virginia

    Howard Kutchai

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  1. Howard Kutchai
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Kutchai, H. Uptake of sorbitol by chick embryo heart cells at various stages of development. J. Membrain Biol. 24, 225–235 (1975). https://doi.org/10.1007/BF01868624

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  • DOI: https://doi.org/10.1007/BF01868624

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