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Role of tyrosine kinases in lymphocyte activation: Targets for drug intervention

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Abstract

Recent developments in our understanding of lymphocyte receptor-associated signalling events have offered many new potential targets for modifying antigen and cytokine receptor signalling events in immune-related diseases such as allergy, autoimmunity and transplant rejection. As discussed below, these targets are largely tissue-restricted and are functionally confined to a limited set of receptors. Therefore, it is anticipated that selective inhibitors of these signalling events would offer safe and effective therapies for immunologically-based diseases. First, we review T and B cell antigen receptor signalling as targets for inhibiting lymphocyte responses. Second, targets in lymphocyte cytokine receptor signalling pathways are discussed. Finally, we review strategies for inhibition of receptor signalling.

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    J. H. Hanke, B. A. Pollok & P. S. Changelian

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Hanke, J.H., Pollok, B.A. & Changelian, P.S. Role of tyrosine kinases in lymphocyte activation: Targets for drug intervention. Inflamm Res 44, 357–371 (1995). https://doi.org/10.1007/BF01797862

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