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Intra-articular injection of stromelysin into rabbit knees as a model to evaluate matrix metalloprotease inhibitors

  • I. Cartilage degradation and osteoarthritis
  • Published:
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References

  1. O'Byrne EM, Blancuzzi V, Wilson DE, Wong M, Jeng A. Elevated substance p and accelerated cartilage degradation in rabbit knees injected with interleukin-1 and tumor necrosis factor. Arthritis Rheum 1990;33:1023–7.

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  2. Goldberg RL, Kolibas LM. An improved method for determining proteoglycans synthesized by chondrocytes in culture. Conn Tiss Res 1990;24:265–75.

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  3. Thonar EJM, Lenz ME, Klinsworth GK, Caterson B, Pachman LM, Glickman P, et al. Quantification of keratan sulfate in blood as a marker of cartilage catabolism. Arthritis Rheum 1985;28:1367–76.

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Authors and Affiliations

  1. Research Department, Pharmaceuticals Division, Ciba-Geigy Corporation, 07901, Summit, NJ, USA

    R. L. Goldberg, D. Parker, L. MacPherson, V. Ganu, R. Melton, S. -I. Hu, V. Blancuzzi, D. Wilson, J. Doughty, S. Spirito & E. O'Byrne

Authors
  1. R. L. Goldberg
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  2. D. Parker
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  3. L. MacPherson
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  4. V. Ganu
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  5. R. Melton
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  6. S. -I. Hu
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  7. V. Blancuzzi
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  8. D. Wilson
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  9. J. Doughty
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  10. S. Spirito
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  11. E. O'Byrne
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Goldberg, R.L., Parker, D., MacPherson, L. et al. Intra-articular injection of stromelysin into rabbit knees as a model to evaluate matrix metalloprotease inhibitors. Inflamm Res 44 (Suppl 2), S115–S116 (1995). https://doi.org/10.1007/BF01778289

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  • DOI: https://doi.org/10.1007/BF01778289

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