Summary
Intravenous drug abusers have a deficit of monocyte chemotaxis. “In vitro” ascorbic acid restores the impaired chemotaxis.
Abbreviations
- CI:
-
Chemotactic index
- EAS:
-
Endotoxin-activating serum
- IDA:
-
Intravenous drug abusers
- PBM:
-
Peripheral blood monocytes
References
Boxer LA, Watanave AM, Rister M et al. (1976) Correction of leukocyte function in Chediak-Higashi syndrome by ascorbate. N Engl J Med 295:1041–1045
Brown SM, Stimmel B, Taub RN, Koch WAS, Rosenfield R (1974) Immunologic dysfunction in heroin addicts. Arch Intern Med 134:1001–1006
Cherubin CE (1971) Infectious disease problems of narcotic addicts. Arch Intern Med 128:309–313
Gallin JI, Sandler JA, Clyman RI, Manganiello VC, Vaughan M (1978) Agents that increase cyclic AMP inhibit accumulation of cGMP and depress human monocyte locomotion. J Immunol 120:492–496
Poli G, Bottazi B, Acero R et al. (1985) Monocyte function in intravenous drug abusers with lymphadenopathy syndrome and in patients with acquired immunodeficiency syndrome: selective impairment of chemotaxis. Clin Exp Immunol 62:136–142
Poli G, Introna M, Zanaboni F et al. (1985) Natural killer cells in intravenous drug-abusers with lymphadenopathy syndrome. Clin Exp Immunol 62:128–135
Snyderman R, Altman LC, Harsman Ms, Mergenhager SH (1972) Human mononuclear leucocyte chemotaxis: a quantitative assay for humoral and cellular chemotactic factors. J Immunol 108:857–860
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lopez, A.J., Palomo, D.G., Castrillon, J.L.P. et al. “In vitro” improvement of defective monocyte chemotaxis in intravenous drug abusers after incubation with ascorbic acid. Klin Wochenschr 65, 625–626 (1987). https://doi.org/10.1007/BF01726674
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01726674