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Circannual variation in the expression of β2-adrenoceptors on human peripheral mononuclear leukocytes (MNLs)

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Summary

Peripheral mononuclear leukocytes (MNLs) are widely used as a tissue model in studies of β-adrenoceptor disturbances in hypertension and asthmatic diseases. The β2-adrenoceptor density (Bmax), however, depends not only on the gender of the person under study and on the time of day the blood specimens are obtained. Evidence is now reported for a circannual variation in the expression of β2-adrenoceptor sites on peripheral MNLs. In male volunteers the 24-h mean was found to be highest in the men studied in April/May (1135±10 sites/cell) and decreased to 891±16 sites/cell in August and to 712±90 sites/cell in December (±SE,P<0.01 April/May compared to December). Concomitantly the circadian amplitude increased from 17.3%±6.4% of 24-h mean in April/May to 28.2%±1.4% of 24-h mean in August and to 34.2%±4.2% of 24-h mean in December (±SE,P<0.05, April/May compared to December). The circadian acrophase remained constant (190°±30° equivalent to 12 h 40 min±2 h 00 min, ±SE).

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Abbreviations

MNLs:

Peripheral mononuclear leucocytes

Bmax :

β2-Adrenoceptor density

125ICYP:

125Iodo-cyanopindolol

PEF:

Peak expiratory flow

SE:

Standard error

ANOVA:

Analysis of variance

M:

Circadian mesor

A:

Circadian amplitude

φ:

Circadian acrophase

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Authors and Affiliations

  1. Walther-Straub-Institut für Pharmakologie und Toxikologie, München

    E. Haen, I. Langenmayer, A. Pangerl, B. Liebl & J. Remien

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  1. E. Haen
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  2. I. Langenmayer
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  3. A. Pangerl
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  4. B. Liebl
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  5. J. Remien
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Haen, E., Langenmayer, I., Pangerl, A. et al. Circannual variation in the expression of β2-adrenoceptors on human peripheral mononuclear leukocytes (MNLs). Klin Wochenschr 66, 579–582 (1988). https://doi.org/10.1007/BF01720832

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  • DOI: https://doi.org/10.1007/BF01720832

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