Skip to main content
Log in

Sepsis syndrome induced by tuberculous perforation of the esophagus

Sepsis-Syndrom durch eine tuberkulosebedingte Ösophagusperforation

  • Case Report
  • Published:
Infection Aims and scope Submit manuscript

Summary

Perforation of the esophagus induced by tuberculosis with no evidence of HIV infection is an extremely unusual presentation of the disease. We report on a 41-year-old man presenting with an esophageal perforation who developed a sepsis syndrome characterized by multiple organ dysfunction. The perforation was covered endoscopically with a tube, the patient recovered from cardiovascular, renal and pulmonary dysfunction under intensive care treatment, including antimycobacterial therapy. In response to endoscopic and medical treatment the size of the lesion decreased and disappeared 56 days after diagnosis. The patient could be discharged 2 months after admission and remained asymptomatic after a 12 month follow-up examination.

Zusammenfassung

Eine durch Tuberkulose bedingte Ösophagusperforation ist eine seltene Komplikation der Tuberkulose. Wir stellen einen 41-jährigen Mann mit einer Perforation im Rahmen einerMycobacterium tuberculosis-Infektion vor, bei dem kein eindeutiger Hinweis auf einen pulmonalen Ursprung vorlag und eine HIV-Infektion ausgeschlossen werden konnte. Dieser Patient entwickelte ein Sepsis-Syndrom, welches durch eine kardiovaskuläre, renale und pulmonale Dysfunktion charakterisiert war. Die Perforation wurde endoskopisch mit einem Tubus überbrückt und der Patient erholte sich unter intensivmedizinischer und antimykobakterieller Therapie. Die Läsion war nach 56 Tagen nicht mehr erkennbar, der Patient konnte 2 Monate nach Aufnahme entlassen werden und ist nach 1 Jahr asymptomatisch geblieben.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Abel, M. E., Chiu, Y. S., Russell, T. R., Volpe, P. Gastrointestinal tuberculosis. Report of four cases. Dis. Colon Rectum 33 (1990) 886–889.

    Google Scholar 

  2. Marshall, J. B. Tuberculosis of the gastrointestinal tract and peritoneum. Am. J. Gastroenterol. 88 (1993) 989–999.

    Google Scholar 

  3. Eng, J., Sabanathan, S. Tuberculosis of the esophagus. Dig. Dis. Sci. 36 (1991) 536–540.

    Google Scholar 

  4. Friedenberg, K. A., Draguesku, J. O., Kiyabu, M., Valenzuela, J. E. Intestinal perforation due toM. tuberculosis in HIV-infected individuals: report of 2 cases. Am. J. Gastroenterol. 88 (1993) 604–607.

    Google Scholar 

  5. Raghu, G., Dillard, D. Esophagobronchial fistula and mediastinal tuberculosis. Ann. Thorac. Surg. 50 (1990) 647–649.

    Google Scholar 

  6. Agarwal, M. K., Muthuswamy, P. P., Shah, R. S., Addington, W. W. Respiratory failure in pulmonary tuberculosis. Chest 72 (1977) 605–609.

    Google Scholar 

  7. Guth, A. A., Kim, U. The reappearance of abdominal tuberculosis. Surg. Gynecol. Obstet. 172 (1991) 432–436.

    Google Scholar 

  8. Newman, R. M., Fleshner, P. R., Lajam, F. E., Kim, U. Esophageal tuberculosis: a rare presentation with hematemesis. Am. J. Gastroenterol. 86 (1991) 751–755.

    Google Scholar 

  9. Gordon, A. H., Marshall, J. B. Esophageal tuberculosis: definitive diagnosis by endoscopy. Am. J. Gastroenterol. 85 (1990) 174–177.

    Google Scholar 

  10. Bone, R. C., Sprung, C. L., Sibbald, W. J. Definitions for sepsis and organ failure. Crit. Care Med. 20 (1992) 724–726.

    Google Scholar 

  11. Lowry, S. E. Cytokine mediators of immunity and inflammation. Arch. Surg. 128 (1993) 1235–1241.

    Google Scholar 

  12. Adams, L. B., Fukutomi, Y., Krahenbuhl, J. L. Regulation of murine macrophage effector functions by lipoarabinomannan from mycobacterial strains with different degree of virulence. Infect. Immun. 61 (1993) 4173–4181.

    Google Scholar 

  13. Murray, H. W., Tuazon, C. U., Kirman, N., Sheagren, J. N. The adult respiratory distress syndrome associated with miliary tuberculosis. Chest 73 (1978) 37–40.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schröder, J., Vogel, I., Thybusch, A. et al. Sepsis syndrome induced by tuberculous perforation of the esophagus. Infection 24, 162–163 (1996). https://doi.org/10.1007/BF01713329

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01713329

Keywords

Navigation