Summary
Several factors must be considered before the clinical impact of antimicrobials on the immune function can be determined. No data are available as yet on the influence of ofloxacin, a new fluoro-quinolone, on the lymphocytes of Peyer's patches. The present study offers evidence that murine Peyer's patches are influenced by ofloxacin administered by the oral route for seven days (15 mg/kg). No modifications of the percentage of the Thy 1,2 and SIg positive splenocytes and of the PHA and LPS-induced proliferative responses were observed studying cell suspensions from the spleen of the same animals. An immunotoxic effect of the compound on the cells of Peyer's patches or an impairment of their homing tendency has been postulated.
Zusammenfassung
Die Beurteilung einer Beeinflussung des Immunsystems durch antimikrobielle Substanzen erfordert die Berücksichtigung einer Vielzahl von Faktoren. Bislang liegen keine Daten darüber vor, ob Ofloxacin, ein neues fluoriertes Chinolon, Einfluß auf Lymphozyten der Peyerschen Plaques hat. In der vorliegenden Studie wird belegt, daß die Medikation von Mäusen mit 15 mg Ofloxacin pro kg Körpergewicht oral für sieben Tage die Peyerschen Plaques beeinflußt. Der Prozentsatz an Thy 1,2 — und SIg-positiven Milzzellen und die Proliferationsantwort auf PHA und LPS, die an Suspensionen von Milzzellen derselben Tiere geprüft wurden, waren hingegen unverändert. Es wird angenommen, daß Ofloxacin entweder eine immuntoxische Wirkung auf Zellen der Peyerschen Plaques hat oder ihr Homing beeinflußt.
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Simone, D., Zanzoglu, S., Santini, G. et al. Influence of ofloxacin on murine Peyer's patch lymphocytes. Infection 14 (Suppl 4), S256–S257 (1986). https://doi.org/10.1007/BF01661287
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DOI: https://doi.org/10.1007/BF01661287