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Acute sporadic non-A, non-B hepatitis in a pediatric population living in Cairo, Egypt

Akute, sporadisch auftretende Non-A, Non-B-Hepatitis bei ägyptischen Kindern in Kairo

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Summary

One-hundred and four cases of acute viral hepatitis and 100 controls 13 years of age and less were entered into a study of acute hepatitis in children in Cairo, Egypt. Study subjects, who were mainly from a lower socioeconomic level, were selected from a public pediatric clinic. Acute non-A, non-B hepatitis was diagnosed in 51 (49%) patients, hepatitis A in 46 (44%), possible hepatitis B in three (3%), and EBV hepatitis in four (4%) patients. Contact with a family member with jaundice was found to be significantly associated with hepatitis A. A history of a blood transfusion, a medical injection, and knowledge of an individual outside of the household with jaundice during the prior six months were significantly associated with non-A, non-B hepatitis. A significant association was not found between the type of hepatitis and the age and gender of study subjects and the extent of household crowding. In this pediatric population living in an urban area of a developing country, non-A, non-B hepatitis was found to be a major cause of acute sporadic hepatitis.

Zusammenfassung

In einer Studie zur akuten Hepatitis bei ägyptischen Kindern in Kairo wurden 104 Fälle mit akuter Virushepatitis und 100 Kontrollfälle im Alter von bis zu 13 Jahren analysiert. Die Untersuchung erfolgte an Patienten eines pädiatrischen Allgemeinkrankenhauses, die Kinder kamen vorwiegend aus der unteren sozioökonomischen Schicht. Bei 51 der Kinder (49%) wurde eine akute Non-A, Non-B-Hepatitis diagnostiziert, bei 46 (44%) eine A-Hepatitis, bei drei (3%) eine mögliche B-Hepatitis und bei vier (4%) eine EBV-Hepatitis. Die Hepatitis A war eindeutig assoziiert mit Kontakt zu einem Familienmitglied mit ikterischer Erkrankung. Die Non-A, Non-B-Hepatitis wies eine signifikante Assoziation mit vorausgegangener Bluttransfusion, therapeutischer Injektion und mit Fällen ikterischer Erkrankung, die bei Personen außerhalb des Haushalts sechs Monate vor Erkrankung des Kindes aufgetreten waren, auf. Der Hepatitistyp korrelierte nicht mit dem Alter und Geschlecht des untersuchten Patienten und der Enge der Wohnverhältnisse. Bei pädiatrischen Patienten aus dem städtischen Wohnbereich eines Entwicklungslandes erwies sich die Non-A, Non-B-Hepatitis als eine der Hauptursachen der akuten, sporadisch auftretenden Hepatitis.

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Authors and Affiliations

  1. Epidemiology Division, Naval Medical Research Institute, 20814-5055, Bethesda, MD, USA

    K. C. Hyams M. D.

  2. U. S. Naval Medical Research Unit No. 3 (NAMRU-3, Cairo, Egypt), FPO, 09527, New York, USA

    M. McCarthy M. D., M. M. Mansour Ph. D. & I. Z. Imam M. D.

  3. Department of Pediatrics, Ain Shams University, Cairo, Egypt

    S. El-Shimy M. D. & Mona El-Samahy M. D.

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  1. K. C. Hyams M. D.
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  2. M. McCarthy M. D.
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  3. M. M. Mansour Ph. D.
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  4. I. Z. Imam M. D.
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  5. S. El-Shimy M. D.
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  6. Mona El-Samahy M. D.
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Hyams, K.C., McCarthy, M., Mansour, M.M. et al. Acute sporadic non-A, non-B hepatitis in a pediatric population living in Cairo, Egypt. Infection 18, 273–276 (1990). https://doi.org/10.1007/BF01647001

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  • DOI: https://doi.org/10.1007/BF01647001

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