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Two rare complications of chronic benzene poisoning: Myeloid metaplasia and paroxysmal nocturnal hemoglobinuria. Report of two cases

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Summary

Two patients, one with myeloid metaplasia and the other one with PNH, both due to chronic exposure to benzene are presented. The patient with PNH exhibited also marked monocytosis as a rare hematologic finding of chronic benzene exposure. The etiological relationship between myeloid metaplasia, PNH and chronic benzene exposure is discussed.

Zusammenfassung

Verfasser stellen vor: Einen Pat, mit myeloischer Metaplasie und einen zweiten mit paroxysmaler nächtlicher Hemoglobinurie (PNH). Beide Krankheiten waren die Folge chronischer Benzolvergiftung. Der Pat. mit PNH litt außerdem an Monozytose, einem seltenen hämatologischen Befund bei chronischer Benzoleinwirkung im Beruf. Die ätiologische Beziehung zwischen myeloischer Metaplasie, PNH und chronischer Benzolvergiftung wird besprochen.

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References

  1. Akman N., Domaniç N. & Müftüoglu A. Ü.: Paroxysmal nocturnal hemoglobinuria: report of a case with features of intravascular consumption coagulopathy. Hacettepe Bull. Med. Surg.4, 159 (1971).

    Google Scholar 

  2. Aksoy M. & Erdem S. Some problems of hemoglobin pattern in different thalassemic syndromes showing the heterogencity of beta-thalassemia. Ann. NY. Acad. Sci.165, 13 (1969).

    Google Scholar 

  3. Aksoy M., Dinçol K., Akgün T., Erdem S. & Dinçol, G.: Haematological effects of chronic benzene poisoning in 217 workers. Brit. J. industr. Med.28, 296 (1971).

    Google Scholar 

  4. Aksoy M., Dinçol K., Erdem S., Akgün T. & Dinçol G.: Details of blood changes in 32 patients with pancytopenia associted with long-term exposure to benzene. Brit. J. industr. Med.29, 56 (1972).

    Google Scholar 

  5. Aksoy M., Dinçol, K., Erdem S. & Dinçol, G.: Acute leukemia due to chronic exposure to benzene. Amer. J. Med.52, 160 (1972).

    Google Scholar 

  6. Aksoy M., Erdem S., Dinçol, K., Hepyüksel T. & Dinçol G.: Chronic exposure to benzene as a possible contributary factor in Hodgkin's disease. Bult28, 293 (1974).

    Google Scholar 

  7. Aksoy M., Erdem S. & Dinçol, G.: Leukemia in shoeworkers exposed chronically to benzene. Blood 44, 837 (1974).

    Google Scholar 

  8. Aksoy M., Erdem S. & Dinçol G.: The types of leukaemia in chronic benzene poisoning. A study in 34 patients. In preparation.

  9. Anderson R. E., Hoshino T. & Yamamoto T.: Myelofibrosis with myeloid metaplasia in survivors of the atomic bomb in Hiroshima. Ann. Intern Med.60, 1 (1964).

    Google Scholar 

  10. Browning E.: Toxicity and Metabolism of Industrial Solvents. p. 41. Elsevier Publ. Comp., Amsterdam 1965.

    Google Scholar 

  11. Cartwright G. E.: Diagnostic Laboratory Hematology 2nd Ed. p. 285, 332. Grune & Stratton, New York 1968.

    Google Scholar 

  12. Gall E. A.: Benzene poisoning with bizarre extramedullary hematopoiesis. Arch. Pathol.25, 315 (1938).

    Google Scholar 

  13. Hartman R. C. & Jenkins Jr. D. E.: The “sugar-water” test for paroxysmal noctural hemoglobinuria. New Engl. J. Med.275, 155 (1966).

    Google Scholar 

  14. McCombs M. & Bowman B. H.: Demonstration of inherited ceruloplasmin variants in human serum by acrylamide gel electrophoresis. Texas Reports Biol. Med.27, 769 (1969).

    Google Scholar 

  15. Rawson R., Parker Jr. F. & Jackson Jr. H.: Industrial solvents as possible etiologic agents in myeloid metaplasia. Science93, 541 (1941).

    Google Scholar 

  16. Savilahti M.: Mehr als Vergiftungsfälle durch Benzol in einer Schuhfabrik. Arch. Gewerbepathol. gewerbehyg.15, 147 (1956).

    Google Scholar 

  17. Sungur T.: Detriments of solvents, p. 53, 58. Basnur Matbaasi, Ankara, 1969.

    Google Scholar 

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This study was supported by a grant (TAG/172) from the Scientific and Technical Research Council of Turkey.

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Aksoy, M., Erdem, S. & Dinçol, G. Two rare complications of chronic benzene poisoning: Myeloid metaplasia and paroxysmal nocturnal hemoglobinuria. Report of two cases. Blut 30, 255–260 (1975). https://doi.org/10.1007/BF01635357

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  • DOI: https://doi.org/10.1007/BF01635357

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