Summary
The expression of vimentin in Reed-Sternberg cells in 61 samples of Hodgkin's disease (HD) was examined using an avidin-biotin-peroxidase complex technique. Forty biopsies (66%) expressed vimentin, and expression was seen in all subtypes of HD. No immunophenotypic differences between vimentin-positive and vimentin-negative cases were noted. The significance of such expression is unclear, but may be related to the alterations in growth and differentiation that are typical of neoplastic cells.
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Angel, C.A., Cullen, R.A., Pringle, J.H. et al. Vimentin expression by reed-Sternberg cells in Hodgkin's disease. Vichows Archiv A Pathol Anat 421, 9–11 (1992). https://doi.org/10.1007/BF01607132
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DOI: https://doi.org/10.1007/BF01607132