Summary
We describe a rare carcinoma of the gallbladder containing osteoclast-like giant cells. Well-differentiated adenocarcinoma was found in the mucosa of the fundus, and osteoclast-like giant cells were present mainly in a haemorrhagic mass protruding from the mucosal surface. The metastatic hepatic tumour was composed chiefly, if not exclusively, of osteoclastoma-like cells, but minute carcinomatous elements were also present. There was an apparent transition between the giant cells and tubular structures in both the gallbladder tumour and hepatic tumour. However, ultrastructural study did not reveal any evidence of epithelial differentiation in the giant cells. Immunohistochemical studies suggested that the mononuclear and giant cells were mesenchymal and histiocytic in nature (vimentin and factor XIII a positive). A few exceptional giant cells transforming from the fine tubular structure were positive for epithelial membrane antigen. In conclusion, the osteoclast-like giant cell tumour component was thought to represent mesenchymal metaplasia in pre-existent adenocarcinoma.
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References
Albores-Saavedra J, Henson DE (1986) Tumors of the gallbladder and extrahepatic bile ducts. In: Atlas of tumor pathology, 2nd series, fascicle 22. Armed Forces Institute of Pathology, Washington, D.C., pp 65–74
Albores-Saavedra J, Cruz-Ortiz H, Alcantara-Vazques A, Henson DE (1981) Unusual types of gallbladder carcinoma. Arch Pathol Lab Med 105:287–293
Alpers CE, Beckstead JH (1985) Malignant neuroendocrine tumor of the jejunum with osteoclast-like giant cells. Enzyme histochemistry distinguishes tumor cells from giant cells. Am J Surg Pathol 9:57–64
Athanasou NA, Wells CA, Quinn J, Ferguson DP, Heryet A, McGee JO (1989) The origin and nature of stromal osteoclastlike multinucleated giant cells in breast carcinoma: implications for tumour osteolysis and macrophage biology. Br J Cancer 59:491–498
Balogh K, Wolbarsht RL, Federman M, O'Hara CJ (1985) Carcinoma of the parotid gland with osteoclastlike giant cells. Immunohistochemical and ultrastructural observations. Arch Pathol Lab Med 109:756–761
Brecher ME, Franklin WA, Simon MA (1986) Immunohistochemical study of mononuclear phagocyte agents in giant cell tumor of bone. Am J Pathol 125:252–257
Dorney P (1967) Osteoclastoma of the heart. Br Heart J 29:276–278
Edmondson HA (1967) Tumors of the gallbladder and extrahepatic bile ducts. In: Atlas of tumor pathology, section 7, fascicle 26. Armed Forces Institute of Pathology, Washington, D.C., pp 84–85
Eshun-Wilson K (1973) Malignant giant-cell tumor of the colon. Acta Pathol Microbiol Scand 81:137–144
Eusebi V, Martin SA, Govoni E, Rosai J (1984) Giant cell tumor of major salivary gland: report of three cases. One occurring in association with a malignant mixed tumor. Am J Clin Pathol 81:666–675
Factor SM, Biempica L, Ratner I, Ahuja KK, Biempica S (1977) Carcinoma of the breast with multinucleated reactive stromal giant cells. A light and electron microscopic study of two cases. Virchows Arch [A] 374:1–12
Fischer HP, Altmannsberger M, Kracht J (1988) Osteoclast-type giant cell tumour of the pancreas. Virchows Arch [A] 412:247–253
Hashimoto H, Koga S, Watanabe H, Enjoji M (1980) Undifferentiated carcinoma of the thyroid gland with osteoclast-like giant cells. Acta Pathol Jpn 30:323–334
Holland R, Van Haelst UJGM (1984) Mammary carcinoma with osteoclast-like giant cells. Additional observations on six cases. Cancer 53:1963–1973
Holtz F, Fox JE, Abell MR (1972) Carcinosarcoma of the urinary bladder. Cancer 29:294–304
Kimura K, Ohnishi Y, Morishita H, Amezaki H, Irikura H (1983) Giant cell tumour of the kidney. Virchows Arch [A] 398:357–365
Kimura K, Ohnishi Y, Kitazawa M, Higuchi M (1984) Giant cell tumor of the gallbladder (in Japanese). Igaku No Ayumi 128:725–726
Kobayashi S, Yamadori I, Ohmori M, Kurokawa T, Ueda M (1987) Anaplastic carcinoma of the thyroid with osteoclast-like giant cells. An ultrastructural and immunohistochemical study. Acta Pathol Jpn 37:807–815
Kuwano H, Sonoda T, Hashimoto H, Enjoji M (1984) Hepatocellular carcinoma with osteoclast-like giant cells. Cancer 54:837–842
Love GL, Daroca PJ Jr (1983) Bronchogenic sarcomatoid squamous cell carcinoma with osteoclast-like giant cells. Hum Pathol 14:1004–1006
Munoz PA, Rao MS, Reddy JK (1980) Osteoclastoma-like giant cell tumor of the liver. Cancer 46:771–779
Nemes Z, Thomazy V (1988) Factor XIIIa and the classic histiocytic markers in malignant fibrous histiocytoma: a comparative immunohistochemical study. Hum Pathol 19:822–829
Oyasu R, Battifora HA, Buckingham WF, Hidvegi D (1977) Metaplastic squamous cell carcinoma of bronchus simulating giant cell tumor of bone. Cancer 39:1119–1128
Prat J, Scully RE (1979) Ovarian mucinous tumors with sarcomalike mural nodules. A report of seven cases. Cancer 44:1332–1344
Ramaekers FCS, Haag D, Kant A (1983) Coexpression of keratin- and vimentin-type intermediate filaments in human metastatic carcinoma cells. Proc Natl Acad Sci USA 80:2618–2622
Robinson L, Damjenow I, Brezina P (1977) Multinucleated giant cell neoplasm of pancreas. Arch Pathol Lab Med 101:590–593
Roholl PJ, Kleyne J, Elbers H, Van der Vegt MC, Albus-Lutter C, Van Unnik JA (1985) Characterization of tumor cells in malignant fibrous histiocytomas and other soft tissue tumors in comparison with malignant histiocytes. I. Immunohistochemical study on paraffin sections. J Pathol 147:87–95
Salon R, Sissons HA (1972) Giant-cell tumors of soft tissues. J Pathol 107:27–39
Trepeta RW, Mathur B, Lagin S, LiVolsi VA (1981) Giant cell tumor (‘osteoclastoma’) of the pancreas: a tumor of epithelial origin. Cancer 48:2022–2028
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Ito, M., Hsu, C.T., Naito, S. et al. Osteoclast-like giant cell tumour of the gallbladder. Vichows Archiv A Pathol Anat 420, 359–366 (1992). https://doi.org/10.1007/BF01600216
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DOI: https://doi.org/10.1007/BF01600216