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Genetic mapping ofPim-1 putative oncogene to mouse chromosome 17

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Somatic Cell and Molecular Genetics

Abstract

Pim-1 is a putative oncogene activated in T-cell lymphomas induced by Moloney and AKR mink cell focus forming (MCF) viruses. We have determined the chromosomal localization of the Pim-1gene in mice by Southern blot analysis of DNAs obtained from a panel of mouse-Chinese hamster somatic cell hybrids. The Pim-1gene was localized on chromosome 17, a chromosome frequently aberrant in T-cell lymphomas. Two chromosomal regions, containing sequences homologous to regions within the Pim-1locus, were localized on chromosome 6 and 16.

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Authors and Affiliations

  1. Department of Tumor Biology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Huis, Plesmanlaan 121, 1066, CX, Amsterdam

    John Hilkens, Vera Kroezen & Jo Hilgers

  2. Department of Biochemistry, University of Nijmegen, Geert Grooteplein N 21, 6521, EZ, Nijmegen, The Netherlands

    H. Theo Cuypers, Gerard Selten & Anton Berns

Authors
  1. John Hilkens
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  2. H. Theo Cuypers
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  3. Gerard Selten
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  4. Vera Kroezen
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  5. Jo Hilgers
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  6. Anton Berns
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Hilkens, J., Theo Cuypers, H., Selten, G. et al. Genetic mapping ofPim-1 putative oncogene to mouse chromosome 17. Somat Cell Mol Genet 12, 81–88 (1986). https://doi.org/10.1007/BF01560730

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  • DOI: https://doi.org/10.1007/BF01560730

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