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Die Bedeutung des Fibrins/Fibrinogens für Wachstum und Metastasierung von Malignomen

The significance of fibrin/fibrinogen for growth and metastasis of malignant tumors

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Summary

It seems evident that fibrinogen and fibrin representing the final substrate und product of clotting system act as pathogenetic connecting links for development and spread of malignant tumors. The results reported demonstrate the influence of fibrin on the initial phase of haematogenic metastasis particularly. Several tumor-specific mechanisms are shown to cause frequently an accumulation of fibrin in malignant tumors. The results discussed here stress the importance of fibrin in tumors for tumor cells and tumor cell units. In the literature a large number of indications to fibrin depositions in experimental tumors is found, an attempt is made to compare these findings semiquantitatively. The last part of this article discusses the therapeutic and diagnostic consequences based on the possible key position of fibrin(ogen) in the tumor pathology.

Zusammenfassung

Fibrinogen und Fibrin, Endsubstrat und Endprodukt des Gerinnungssystems, scheinen bei der Entwicklung und Ausbreitung von Malignomen die Rolle eines pathogenetischen Bindegliedes zu spielen. In der Literatur zeigen die Forschungsergebnisse, daß Fibrin insbesondere in die Initialphase der hämatogenen Metastasierung eingreift. Für die häufig anzutreffende, oft reichliche Fibrinablagerung in Tumoren konnten mehrere tumorspezifische Mechanismen nachgewiesen werden. Die Ergebnisse der zitierten Forschungsarbeiten weisen auf die Bedeutung des intratumorös abgelagerten Fibrins für Tumorzelle und -zellverband hin. Die von verschiedenen Autoren berichteten Fibrinanreicherungen in tierexperimentellen Tumoren werden semiquantitativ verglichen. Die Diskussion der therapeutischen und diagnostischen Konsequenzen, die auf einer möglichen Schlüsselstellung des Fibrin(ogen)s in der Tumorpathologie beruhen, zeigt bekannte und noch zu untersuchende Möglichkeiten.

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  1. Abteilung für Gynäkologie und Geburtshilfe I der Universität Ulm, Germany

    H. Heyes & D. Glück

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Mit Unterstützung des „Landesverbandes Baden-Württemberg zur Erforschung und Bekämpfung des Krebses“

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Heyes, H., Glück, D. Die Bedeutung des Fibrins/Fibrinogens für Wachstum und Metastasierung von Malignomen. Klin Wochenschr 55, 1079–1087 (1977). https://doi.org/10.1007/BF01477934

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