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Human intracranial tumours: Effect of autologous serum addition on leucocyte migration inhibition

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Summary

42 human intracranial tumours were investigated by the leucocyte migration inhibition technique at various antigen concentrations with and without autologous serum addition. A correlation was found between migration rate and antigen concentration. Autologous serum addition resulted in a non-specific stimulation of migration, however, stimulation by immune complexes was also present. Migration stimulation, as an in-vitro-equivalent of immunologic tumour enhancement, is discussed.

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References

  1. Akiyoshi, T., Hata, A., Tsuji, H., In vitro cellular responses to autologous tumor extract detected by inhibition of macrophage migration. GANN66 (1975), 167–174.

    PubMed  Google Scholar 

  2. Andersen, V., Bjerrum, O., Bendixen, G., SchiØdt, T., Dissing, I., Effect of autologous mammary tumor extracts on human leukocyte migration in vitro. Int. J. Cancer5 (1970), 357–363.

    PubMed  Google Scholar 

  3. Baldwin, R. W., Embleton, M. J., Price, M. R., Robins, A., Immunity in the tumor-bearing host and its modification by serum factors. Cancer34 (1974), 1452–1460.

    PubMed  Google Scholar 

  4. Bendixen, G., SØborg, M., A leukocyte migration technique for in vitro detection of cellular (delayed type) hypersensitivity in man. Dan. Med. Bull.16 (1969), 1–5.

    Google Scholar 

  5. Black, M. M., Leis, H. P., Shore, B., Zachran, R. E., Cellular hypersensitivity to breast cancer. Cancer33 (1974), 952–958.

    PubMed  Google Scholar 

  6. Blank, I., Untersuchungen über den Einflu\ von Immunkomplexen auf die in-vitro-Migration von Blutgranulozyten des Menschen. Allergie Immunol.23 (1977), 313–321.

    Google Scholar 

  7. Böker, D.-K., über zellvermittelte Immunreaktionen bei menschlichen Hirntumoren. Neurochirurgia23 (1980), 229–234.

    PubMed  Google Scholar 

  8. Brem, S. S., de Tribolet, N., Dohan, F. C., Kornblith, P. L., Demonstration of cell-mediated immunity to a human brain tumor: Use of an in vitro microcytotoxicity assay. Surg. Forum23 (1972), 428–430.

    PubMed  Google Scholar 

  9. Brooks, W. H., Horwitz, D. A., Netsky, M. G., Evidence for tumor-specific immune response in patients with primary brain tumors. Surg. Forum23 (1972), 430–432.

    PubMed  Google Scholar 

  10. Brostoff, J., “Escape” from leukocyte migration inhibition. J. Immunol. Methods4 (1974), 27–30.

    Google Scholar 

  11. Cerni, C., Der Migrationshemmtest. öst. Ärzteztg.32 (1977), 1200–1205.

    Google Scholar 

  12. Cochran, A. J., Mackie, R. M., Ross, C. E., Ogg, L. J., Jackson, A. M., Leukocyte migration inhibition by cancer patients' sera. Int. J. Cancer18 (1976), 274–281.

    PubMed  Google Scholar 

  13. Elias, E. G., Elias, L. L., Autogenous leukocyte migration in human malignancies. Cancer36 (1975), 1393–1398.

    PubMed  Google Scholar 

  14. Falk, R. E., Mann, P., Langer, B., Cell-mediated immunity to human tumors. Arch. Surg.107 (1973), 261–265.

    PubMed  Google Scholar 

  15. Fritz, J., Grond, K., Der Einflu\ von autologem Serum auf den Leukozyten-Migrations-Inhibitions-Test beim Melanomalignom. Arch. Derm. Res.258 (1977), 121–126.

    Google Scholar 

  16. Gleicher, N., Beers, Ph., Cohen, C. J., Kerenyi, Th. D., Gusberg, S., Leukocyte migration enhancement as an indicator of immunologic enhancement. Amer. J. Obstet. Gynecol.136 (1980), 126–131.

    Google Scholar 

  17. Guillou, J. P., Giles, G. R., Inhibition of leukocyte migration by tumorassociated antigens of the colon and rectum. GUT (1973), 733–738.

  18. Hellström, I., Hellström, K. E., Cell-mediated immune reactions to tumor antigens with particular emphasis on immunity to human neoplasms. Cancer34 (1974), 1461–1468.

    PubMed  Google Scholar 

  19. Kumar, S., Taylor, G., Steward, J. K., Waghe, M. A., Morris-Jones, P., Cell-mediated immunity and blocking facotrs in patients with tumors of the central nervous system. Int. J. Cancer12 (1973), 194–205.

    PubMed  Google Scholar 

  20. Levy, N. L., Specificity of lymphocyte-mediated cytotoxicity in patients with primary intracranial tumors. J. Immunol.21 (1978), 903–015.

    Google Scholar 

  21. McCoy, J. L., Jerome, L. F., Dean, J. H., Perlin, E., Oldham, R. K., Char, D. H., Cohen, M. H., Felix, E. L., Herberman, R. B., Inhibition of leukocyte migration by tumor-associated antigens in soluble extracts of human malignant melanoma. J. Natl. Cancer Inst.55 (1975), 19–23.

    PubMed  Google Scholar 

  22. Nyerges, G., Nyerges, Gy, Molnar, L., Kovacs, F., Leukocyte migration inhibition by brain tissue antigens in acute inflammatory disease of the nervous system. Acta Allergol.29 (1974), 433–443.

    PubMed  Google Scholar 

  23. Pees, H. W., Cytotoxic immune response of meningioma patients towards allogenic and autologous tumor cells before and after surgery. Acta neurochir. (Wien)50 (1979), 217–227.

    Google Scholar 

  24. Sheikh, K. M. A., Apuzzo, M. L. J., Weiss, M. H., Specific cellular immune responses in patients with malignant gliomas. Cancer Res.39 (1979), 1733–1738.

    PubMed  Google Scholar 

  25. SØborg, M., Bendixen, G., Human leukocyte migration as a parameter of delayed hypersensitivity. Acta Med. Scand.181 (1967), 247–255.

    PubMed  Google Scholar 

  26. Weisbart, R. H., Bluestone, R., Goldberg, L. S., Pearson, C. M., Migration enhancement factor: A new lymphokine. Proc. Nat. Acad. Sci. U.S.A.71 (1974), 875–879.

    Google Scholar 

  27. Wolberg, W. H., Inhibition of leukocyte migration by human tumors. Arch. Surg.109 (1974), 211–214.

    PubMed  Google Scholar 

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  1. D. -K. Böker

    Present address: Neurosurgical University Clinic, Bonn, Federal Republic of Germany

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    Böker, D.K. Human intracranial tumours: Effect of autologous serum addition on leucocyte migration inhibition. Acta neurochir 65, 227–237 (1982). https://doi.org/10.1007/BF01405849

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