Summary
Autoantibodies against dopamine receptors in schizophrenic patients have been postulated. IgG was fractionated from sera of 15 schizophrenic patients (DSM III) in an acute episode. However, 3H-spiperone binding to dopamine receptors was not inhibited by this fraction.
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References
Abramsky O, Litvin Y (1978) Autoimmune response to dopamine receptor as a possible mechanism in the pathogenesis of Parkinson's disease and schizophrenia. Perspect Biol Med 22: 104–114
Ahokas A, Koskiniemi ML, Vaheri A, Rimon R (1985) Altered white cell count, protein concentration and oligoclonal IgG bands in the cerebrospinal fluid of many patients with acute psychiatric disorders. Neuropsychology 14: 1–4
Creese I, Burt DR, Snyder SH (1976) Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Science 192: 481–483
Baron M, Stern M, Anavi R, Witz IP (1977) Tissue-binding factor in schizophrenic sera: a clinical and genetic study. Biol Psychiatry 12: 199–216
Heath RG, Krupp IM (1967) Schizophrenia as an immunologic disorder. Arch Gen Psychiatry 16: 1–33
Knight JG (1982) Dopamine-receptor-stimulating autoantibodies: a possible cause of schizophrenia. Lancet II, 1982: 1073–1076
Koliaskina G, Tsutsulkovskaya M, Domashneva I et al. (1980) Antithymic immune factor in schizophrenia. Neuropsychobiology 6: 349–355
Kornhuber HH, Kornhuber J (1987) A neuroimmunological challenge: schizophrenia as an autoimmune disease. Arch Ital Biol 125: in press
Kornhuber J, Bauer K (1986) Störungen der Blut-Liquor-Schranke bei Schizophrenie. Dtsch Med Wochenschr 26: 1041
Legros S, Mendlewicz J, Wybran J (1985) Immunoglobulins, autoantibodies and other serum protein fractions in psychiatric disorders. Eur Arch Psychiatry Neurol Sci 235: 9–11
Lehmann-Facius H (1939) Serologisch-analytische Versuche mit Liquoren und Seren von schizophrenen bzw. atypischen Psychosen. Allg Z Psychiatrie Grenzgeb 110: 232–243
de Lisi LE, Crow TJ (1986) Is schizophrenia a viral or immunologic disorder? Psychiatr Clin North Am 9: 115–132
de Lisi LE, Weber RJ, Pert CB (1985) Are there antibodies against brain in sera from schizophrenic patients? Biol Psychiatry 20: 110–115
de Lisi LE, Weinberger DR, Potkin St et al (1981) Quantitative determination of immunoglobulins in cerebrospinal fluid and plasma of chronic schizophrenic patients. Br J Psychiatry 139: 513–518
Pandey RS, Gupta AK, Chaturvedi UC (1981) Autoimmune model of schizophrenia with special reference to antibrain antibodies. Biol Psychiatry 16: 1123–1136
Pulkkinen E (1977) Immunoglobulins, psychopathology and prognosis in schizophrenia. Acta Psychiatr Scand 56: 173–182
Roos RP, Davis K, Meltzer HY (1985) Immunoglobulin studies in patients with psychiatric diseases. Arch Gen Psychiatry 42: 124–128
Solomon GF, Allansmith M, McClellan B, Amkraut A (1969) Immunoglobulins in psychiatric patients. Arch Gen Psychiatry 20: 272–277
Strahilevitz M, Davis StD (1970) Increased IgA in schizophrenic patients. Lancet II, 1970: 370
Strahilevitz M, Fleischman JB, Fischer GW et al (1976) Immunoglobulin levels in psychiatric patients. Am J Psychiatry 133: 772–777
Torrey EF, Albrecht P, Behr DE (1985) Permeability of the blood-brain barrier in psychiatric patients. Am J Psychiatry 142: 657–658
Watanabe M, Funahashi T, Suzuki T et al (1985) Antithymic antibodies in schizophrenic sera. Biol Psychiatry 17: 699–710
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Kirchbach, A.v., Fischer, E.G. & Kornhuber, H.H. Failure to detect dopamine receptor IgG autoantibodies in sera of schizophrenic patients. J. Neural Transmission 70, 175–179 (1987). https://doi.org/10.1007/BF01252518
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DOI: https://doi.org/10.1007/BF01252518