Abstract
A maximum of 6 STR systems (TH01, VWA, ACTBP2, FES, F13B, D21S11) was investigated in 7 human populations (Germans, Turks, Moroccans, Japanese, Chinese, Papuans, Ovambos). In each population no deviations from Hardy-Weinberg equilibrium were observed. Out of each population the phenotypes of 50 individuals (comprising 3 to 6 STRs) were randomly selected. Based on the phenotype frequencies interpopulation comparisons were carried out using the frequencies of each other population. Within major ethnic groups only minor differences in phenotype frequencies were found. Between major ethnic groups differences of up to several orders of magnitude could be observed. The most discriminative STRs for interpopulation comparisons were TH01, FES and F13B.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Allen RC, Graves G, Budowle B (1989) Polymerase chain reaction amplification products separated on rehydratable polyacrylamide gels and stained with silver. Biotechniques 7:736–744
Alper B, Schürenkamp M, Meyer E (1995) HumFES/FPS and HumF13B: population genetic study on a Turkish and German population survey. Int J Legal Med (submitted)
Brinkmann B, Rand S, Wiegand P (1991) Population and family data of RFLP's using selected single- and multi-locus systems. Int J Legal Med 104:81–86
Brinkmann B, Wiegand P (1993) Medicolegal implications of PCR-based VNTRs. In: Proceedings from the Fifth International Symposium on Human Identification. Promega Corporation, Madison, USA, pp 149–160
Brinkmann B, Sajantila A, Goedde HW, Matsumoto H, Nishi K, Wiegand P (1995) Population genetic comparisons among eight different populations using allele frequency and sequence data from three microsatellite loci. Am J Hum Genet (submitted)
Budowle B, Monson K (1993) The forensic significance of various reference population databases for estimating the rarity of variable number of tandem repeat (VNTR) loci profiles. In: Pena SDJ, Chakraborty R, Epplen JT, Jeffreys AJ (eds) DNA Fingerprinting: State of science. Birkhäuser, Basel
Buscemi L, Cucurachi N, Mencarelli R, Tagliabracci A, Wiegand P, Ferrara SD (1995) PCR analysis of the short tandem repeat (STR) system HUMVWA31. Allele and genotype frequencies in an Italian population sample. Int J Legal Med 107:171–173
Chakraborty R, Kidd KK (1991) The utility of DNA typing in forensic work. Science 254:1735–1739
Edwards A, Hammond HA, Jin L, Caskey CT, Chakraborty R (1992) Genetic variation at five trimeric and tetrameric tandem repeat loci in four human population groups. Genomics 12:241–253
Kimpton CP, Walton A, Gill P (1992) A further tetranucleotide repeat polymorphism in the vWF gene. Hum Mol Genet 1:28
Kimpton CP, Gill P, Walton A, Urquhart A, Millican ES, Adams M (1993) Automated DNA profiling employing multiplex amplification of short tandem repeat loci. PCR Methods Appl 8(3) 13–22
Kubat M, Wiegand P, Brinkmann B (1995) Population genetic study from the Zagreb area using 3 STR systems. Int J Legal Med 107:219–221
Möller A, Wiegand P, Grüschow C, Seuchter SA, Baur MP, Brinkmann B (1994a) Population data and forensic efficiency values for the STR systems HumVWA, HumMBP and Hum FABP. Int J Legal Med 106:183–189
Möller A, Meyer E, Brinkmann B (1994b) Different types of structural variation in STRs: HumFES/FPS, HumVWA and HumD21 S 11. Int J Legal Med 106:319–323
Möller A, Brinkmann B (1994) Locus ACTBP2 (SE33) — Sequencing data reveal considerable polymorphism. Int J Legal Med 106:262–267
Nellemann LJ, Möller A, Morling N (1994) PCR typing of DNA fragments of the short tandem repeat (STR) system HUMTH01 in Danes and Greenland Eskimos. Forensic Sci Int 68:45–51
Nishimura DY, Murray JC (1992) A tetranucleotide repeat for the F13B locus. Nucleic Acids Res 20:1167
Polymeropoulos MH, Rath DS, Xiao H, Merril CR (1991) Tetranucleotide repeat polymorphism at the human c-fes/fps proto-on-cogene (FES). Nucleic Acids Res 19:4791
Polymeropoulos MH, Rath DS, Xiao H, Merril CR (1992) Tetranucleotide repeat polymorphism at the human beta-actin related pseudogene H-beta-Ac-psi-2 (ACTBP2). Nucleic Acids Res 20:1432
Puers C, Hammond HA, Jin L, Caskey T, Schumm J (1993) Identification of repeat sequence heterogeneity at the polymorphic short tandem repeat locus HUMTHOI (AATG)n and reassignment of alleles in population analysis by using a locus-specific alleleic ladder. Am J Hum Genet 53:953–958
Rand S, Puers C, Skowasch K, Wiegand P, Budowle B, Brinkmann B (1992) Population genetics and forensic efficiency data of 4 AMPFLPs. Int J Legal Med 104:329–333
Sajantila A, Pacek P, Lukka M, Syvänen AC, Nokelainen P, Sistonen P, Peltonen L, Budowle B (1994) A microsatellite polymorphism in the von Willebrand Factor gene: comparison of the allele frequencies in different population samples and evaluation for forensic medicine. Forensic Sci Int 68:91–102
Sharma V, Litt M (1992) Tetranucleotide repeat polymorphism at the D21S11 locus. Hum Mol Genet 1:67
Wiegand P, Bajanowski T, Brinkmann B (1993a) DNA typing of debris from fingernails. Int J Legal Med 106:81–84
Wiegand P, Budowle B, Rand S, Brinkmann B (1993b) Forensic validation of the STR systems SE33 and TC 11. Int J Legal Med 105:315–320
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Meyer, E., Wiegand, P. & Brinkmann, B. Phenotype differences of STRs in 7 human populations. Int J Leg Med 107, 314–322 (1995). https://doi.org/10.1007/BF01246881
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01246881