Skip to main content
SpringerLink
Log in

Regional effects of neurotensin on the electrically stimulated release of [3H]dopamine and [14C]acetylcholine in the rat nucleus accumbens

  • Original Articles
  • Published:
Neurochemical Research Aims and scope Submit manuscript

Abstract

This study has shown that neurotensin (NT) increases the electrically stimulated release of [3H]DA to a similar extent in all but the extreme caudolateral area of the rat nucleus accumbens and appears to modulate DA release equally in the medial and lateral zones of this brain area. The simultaneous release of ACh was not significantly affected by NT.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Chronister, R. B., Sikes, R. W., Wood, J., and DeFrance, J. F. 1980. The pattern of termination of ventral tegmental afferents into nucleus accumbens: an anterograde HRP analysis. Neurosci. Letters 17:231–235.

    Google Scholar 

  2. Allin, R., Russell, V. A., Lamm, M. C. L., and Taljaard, J. J. F. 1988. Regional distribution of monoamines in the nucleus accumbens of the rat. Neurochem. Res. 13:937–942.

    Google Scholar 

  3. Zahm, D. S. 1987. Neurotensin-immunoreactive neurons in the ventral striatum of the adult rat: ventromedial caudate-putamen, nucleus accumbens and olfactory tubercle. Neurosci. Letters 81:41–47.

    Google Scholar 

  4. Kalivas, P. W., and Miller, J. S. 1984. Neurotensin neurons in the ventral tegmental area project to the medial nucleus accumbens. Brain Res. 300:157–160.

    Google Scholar 

  5. Quirion, R. 1983. Interaction between neurotensin and dopamine in the brain: An overview. Peptides 4:609–615.

    Google Scholar 

  6. Nemeroff, C. B. 1986. The interaction of neurotensin with dopaminergic pathways in the central nervous system: Basic neurobiology and implications for the pathogenesis and treatment of schizophrenia. Psychoneuroendocrinol. 11:15–37.

    Google Scholar 

  7. Dilts, R. P., and Kalivas, P. W. 1989. Autoradiographic localization of μ-opioid and neurotensin receptors within the mesolimbic dopamine system. Brain Res. 488:311–327.

    Google Scholar 

  8. Churchill, L., Dilts, R. P., and Kalivas, P. W. 1990. Changes ingamma-aminobutyric acid, μ-opioid and neurotensin receptors in the accumbens-pallidal projection after discrete quinolinic acid lesions in the nucleus accumbens. Brain Res. 511:41–54.

    Google Scholar 

  9. Reyneke, L., Russell, V. A., and Taljaard, J. J. F. 1987. The modulatory effect of neurotensin of [3H]dopamine release from rat nucleus accumbens slices is enhanced after chronic dispramine treatment. Brain Res. 425:114–119.

    Google Scholar 

  10. Reyneke, L., Russell, V. A., and Taljaard, J. J. F. 1989. Lack of effect of desipramine treatment on dopaminergic activity in the nucleus accumbens of the rat. Neurochemical Res. 14:661–665.

    Google Scholar 

  11. Schotte, A., and Leysen, J. E. 1989. Autoradiographic evidence for the localization of high affinity neurotensin binding sites on dopaminergic nerve terminals in the nigrostriatal and mesolimbic pathways in rat brain. J. Chem. Neuroanat. 2:253–257.

    Google Scholar 

  12. Kalivas, P. W., Richardson-Carlson, R., and Duffy, P. 1986. Neuromedin N mimics the actions of neurotensin in the ventral tegmental area but not in the nucleus accumbens. J. Pharmacol. Exp. Ther. 238:1126–1131.

    Google Scholar 

  13. Ervin, G. N., and Nemeroff, C. B. 1988. Antagonization of the behavioural activation produced by direct stimulation of forebrain dopamine receptors caused by intra-accumbens injections of neurotensin. Neuropsychopharmacol. 1:234–250.

    Google Scholar 

  14. Loopuijt, L. D. 1988. Distribution of dopamine D-2 receptors in the rat striatal complex and its comparison with acetylcholinesterase. Brain Res. Bull. 22:805–817.

    Google Scholar 

  15. Reyneke, L., Russell, V. A., and Taljaard, J. J. F. 1990. Evidence that the stimulatory effect of neurotensin on dopamine rolease in rat nucleus accumbens slices is enhanced after chronic desipramine treatment. Brain Res. 534:188–194.

    Google Scholar 

  16. Palkovits, M., and Brownstein, M. J. 1988. Maps and guide to microdissection of the brain. Elsevier, Amsterdam. pp.23.

    Google Scholar 

  17. Talmaciu, R. K., Hoffmann, I. S., and Cubeddu, L. X. 1986. Dopamine autoreceptors modulate dopamine release from the prefrontal cortex. J. Neurochem. 47:865–870.

    Google Scholar 

  18. Hyttel, J., and Larsen, J.-J. 1985. Acta Pharmacol. Toxicol. 56:146–153.

    Google Scholar 

  19. Schotte, A., Leysen, J. E., and Laduron, P. M. 1986. Evidence for a displaceable non-specific [3H]neurotensin binding site in rat brain. Naunyn-Schmiedeberg's Archives of Pharmacol. 33:400–405.

    Google Scholar 

  20. Schotte, A., and Leysen, J. E. 1989. Autoradiographic evidence for the localization of high affinity neurotensin binding sites on dopaminergic nerve terminals in the nigrostriatal and mesolimbic pathways in rat brain. J. Chem. Neuroanat. 2:253–257.

    Google Scholar 

  21. Meredith, G. E., Blank, B., and Groenewegen, H. J. 1989. The distribution and compartmental organization of the cholinergic neurons in the nucleus accumbens of the rat. Neurosci. 31:327–345.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. MRC Research Unit for the Neurochemistry of Mental Diseases, Department of Chamical Pathology, University of Stellenbosch, Tygerberg Hospital, P. O. Box 19113, 7505, Tygerberg, South Africa

    Louise Reyneke, Vivienne Ann Russell & Joshua Joachim Fransua Taljaard

Authors
  1. Louise Reyneke
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Vivienne Ann Russell
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Joshua Joachim Fransua Taljaard
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Reyneke, L., Russell, V.A. & Taljaard, J.J.F. Regional effects of neurotensin on the electrically stimulated release of [3H]dopamine and [14C]acetylcholine in the rat nucleus accumbens. Neurochem Res 17, 1143–1146 (1992). https://doi.org/10.1007/BF00967292

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00967292

Key Words

Search

Navigation