Abstract
We measured urinary albumin excretion in 2,224 school-children (1,168 boys, 1,056 girls) aged 2–18 years, between 1989 and 1990 to establish reference values. We recorded all pathological antecedents and findings from physical examination, including anthropometric parameters and arterial blood pressure. The analytical study included serum total protein, albumin and creatinine. The second-morning urine and the nightly (rest) 10-h urine sample were collected and we determined the concentration of albumin and creatinine. We found a positive statistically significant correlation between the urinary albumin excretion (μg/10 h) and age, height, weight and body surface area. We suggest that it would be useful to relate the urinary albumin excretion to body surface area. The mean value for albumin excretion was 3.49 μg/ml in boys and 3.63 μg/ml in girls. The urinary albumin/creatinine ratio showed a high correlation with the albumin excretion (r=0.958).
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Viberti GC, Jarret RJ, Mahmud U, Hill RD, Argyropoulos A, Keen H (1982) Microalbuminuria as a predictor of clinical nephropathy in insulin-dependent diabetes mellitus. Lancet II:1430–1432
Blanche M Chavers, Rudolf W Bilous, Eileen N Ellis, Michael W Steffes, Michael Mauer S (1989) Glomerular lesions and urinary albumin excretion in type I diabetes without overt proteinuria. N Engl J Med 320:966–970
Ellis D, Becker DJ, Daneman D, Lobes L Jr, Dragh AL (1983) Proteinuria in children with insulin dependent diabetes: relationship to duration of disease, metabolic control and retinal changes. J Pediatr 102:673–680
Mogensen CE (1984) Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. N Engl J Med 310:356–360
Mogensen CE, Christiensen CK (1984) Predicting diabetic nephropathy in insulin dependent patients. N Engl J Med 311:89–93
Parving HH, Hommel E, Mathiegen E, Skott P, Edsberg B, Bahnsen M, Lauritzen M, Hougaard P, Lauritzen E (1988) Prevalence of microalbuminuria, arterial hypertension, retinopathy and neuropathy in patients with insulin dependent diabetes. BMJ 296: 156–160
Erman A, Van Dyk DJ, Rabinov M, Boner G, Rosenfeld JB (1990) Urinary albumin excretion in the healthy population. Isr J Med Sci 26:389–392
Elises JS, Griffiths PD, Hocking MD, Taylor CM, White RHR (1988) Simplified quantification of urinary protein excretion in children. Clin Nephrol 30:225–229
Kawakami H, Murakami T, Kajii T (1990) Normal values for 24-b urinary protein excretion: total and low molecular weight proteins with a sex related difference. Clin Nephrol 33:232–236
Houser M (1984) Assessment of proteinuria using random urine samples. J Pediatr 104:845–848
Chambers RE, Bullock DG, Whicher JT (1989) Urinary total protein estimation — fact or fiction? Nephron 53:33–36
Miltenyi M (1979) Urinary protein excretion in healthy children. Clin Nephrol 12:216–221
Rowe DJF, Bagga H, Betts PB (1985) Normal variations in rate of albumin excretion and albumin to creatinine ratio in overnight and daytime urine collections in nondiabetic children. BMJ 291: 693–694
Houser MT, Jahn MF, Kobayashi A, Walburn J (1986) Assessment of urinary protein excretion in the adolescent: effect of body position and exercise. J Pediatr 109:556–561
Davies AG, Postlethwaite RJ, Price DA, Burn JL, Houlton CA, Fielding BA (1984) Urinary albumin excretion in school children. Arch Dis Child 59:625–630
Tiezt NW (1972) Química médica moderna. Interamericana, Mèxico, p 970
Schwartz GJ, Gauthier B (1985) A simple estimate of glomerular filtration rate in adolescent boys. J Pediatr 106:522–526
Schwartz GJ, Haycock GB, Edelman CM Jr, Spitzer A (1976) A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics 58:259–263
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The following members are co-authors of this report: N. Caballo, M. A. Arias, C. Serna, M. Ramirez and A. Cornejo
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Sanchez-Bayle, M., Rodriguez-Cimadevilla, C., Asensio, C. et al. Urinary albumin excretion in Spanish children. Pediatr Nephrol 9, 428–430 (1995). https://doi.org/10.1007/BF00866717
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DOI: https://doi.org/10.1007/BF00866717