Abstract
Pulmonary deposition of technetium 99m methylene diphosphonate was found on a bone scan of a patient with undiagnosed primary AL amyloidosis. Unusual clinical manifestations during the course of the disease led to a post-mortem diagnosis. The mechanisms for pulmonary and other ectopic soft tissue bone scan tracer depositions, as well as their significance in the diagnosis of amyloidosis, are discussed.
References
Bekerman C, Vyas MI (1976) Renal localization of Ga-67-citrate in renal amyloidosis: case reports. J Nucl Med 17:899–901
Celli BT, Rubinow A, Cohen AS, Brody JS (1978) Patterns of pulmonary involvement in systemic amyloidosis. Chest 74:543–547
Cordier JF, Loire R, Brune J (1986) Amyloidosis of the lower respiratory tract. Chest 90:827–831
Falk RH, Lee VW, Rubinow A, Hood WB, Cohen AS (1983) Sensitivity of technetium-99m-pyrophosphate scintigraphy in diagnosing cardiac amyloidosis. Am J Cardiol 51:826–830
Gertz MA, Brown ML, Hauser MF, Kyle RA (1987) Utility of technetium-99m pyrophosphate bone scanning in cardiac amyloidosis. Arch Intern Med 147:1039–1044
Gertz MA, Brown ML, Hauser ME, Kyle RA (1990) Utility of gallium imaging of the kidneys in diagnosing primary amyloid nephrotic syndrome. J Nucl Med 31:292–295
Hawkins PN, Myers MJ, Lavender JP, Pepys MB (1988) Diagnostic radionuclide imaging of amyloid: biological targeting by circulating human serum amyloid P component. Lancet I:1413–1418
Kanoh T, Uchino H, Yamamoto I, Torizuka K (1986) Soft-tissue uptake of technetium-99m MDP in multiple myeloma. Clin Nucl Med 11:878–879
Kline LR, Dise CA, Ferro TJ, Hansen-Flaschen JH (1985) Diagnosis of pulmonary amyloidosis by transbronchial biopsy. Am Rev Respir Dis 132:191–194
Koizumi K, Tonami N, Hisada K (1981) Diffusely increased Tc99m-MDP uptake in both kidneys. Clin Nucl Med 6:362–365
Kula RW, Engel WK, Line BR (1977) Scanning for soft-tissue amyloid. Lancet I:92–93
Kyle RA, Greipp PR (1983) Amyloidosis. Mayo Clin Proc 58:665–683
Lee VW, Caldarone AG, Falk RH, Rubinow A, Cohen AS (1983) Amyloidosis of heart and liver: comparison of Tc-99m pyrophosphate and Tc-99m methylene diphosphonate for detection. Radiology 148:239–242
Lee VW, Robinow A, Pehrson J, Skinner M, Cohen AS (1984) Amyloid goiter: preoperative scintigraphic diagnosis using Tc99m-pyrophosphate. J Nucl Med 25:468–471
Mathews WH (1954) Primary systemic amyloidosis. Am J Med Sci 288:317–333
Shtrasburg S, Pras M, Langevitch P, Gal R (1982) Demonstration of AA-protein in formalin-fixed, paraffin embedded tissues. Am J Pathol 106:141–144
Toriumi J (1972) The lung in generalized amyloidosis. Acta Pathol Jpn 22:141–153
van Rijswijk MH, van Heusden WGS (1979) The potassium permanganate method. Am J Pathol 97:43–58
Vonek JA, Cook SA, Bukowsky RM (1977) Hepatic uptake of Tc-99m-labeled diphosphonate in amyloidosis: case report. J Nucl Med 18:1086–1088
Yood RA, Skinner A, Cohen AS, Lee VW (1981) Soft tissue uptake of bone seeking radionuclide in amyloidosis. J Rheumatol 8:760–766
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Zwas, S.T., Shpilberg, O., Huszar, M. et al. Isolated ectopic lung uptake of technetium 99m methylene diphosphonate on bone scintigraphy in primary amyloidosis. Eur J Nucl Med 17, 282–285 (1990). https://doi.org/10.1007/BF00812371
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DOI: https://doi.org/10.1007/BF00812371