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Synthese von neuen bifunktionellen Maleinimidverbindungen zur Herstellung von Chemoimmunokonjugaten

Synthesis of new bifunctional maleimide compounds for the preparation of chemoimmunoconjugates

  • Organische Chemie Und Biochemie
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Summary

Bifunctional maleimide compounds are suitable for binding small molecules to carrier proteins in that they bind to the sulfhydryl group of proteins through the double bond of the maleimide group and to molecules of low molecular weight (e.g. anticancer drugs) through a functional groupX. 18 maleimide compounds of the general formula Maleimid-R-X (R=phenylene, benzyl-, methylene-, ethylene, or am-benzoylethylamide group andX=hydroxy-, amino-, hydrazino-, carboxylic acid-, carboxylic anhydride-, carboxylic acid chloride-, carboxylic acid hydrazide-, oxycarbonylchloride-, aldehyde, keto-, orp-toluenesulfonate-group) were synthesized and characterized through1H- and13C-NMR-spectroscopy, elemental analysis, and mass spectrometry.

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Authors and Affiliations

  1. Abteilung Klinische Forschung, Klinik für Tumorbiologie, D-79106, Freiburg, Bundesrepublik Deutschland

    U. Beyer, M. Krüger, P. Schumacher, C. Unger & F. Kratz

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  1. U. Beyer
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  2. M. Krüger
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  3. P. Schumacher
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  4. C. Unger
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  5. F. Kratz
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Beyer, U., Krüger, M., Schumacher, P. et al. Synthese von neuen bifunktionellen Maleinimidverbindungen zur Herstellung von Chemoimmunokonjugaten. Monatsh Chem 128, 91–102 (1997). https://doi.org/10.1007/BF00807643

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  • DOI: https://doi.org/10.1007/BF00807643

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