Summary
Male inbred rats (Wag) with aorto-caval fistula were used as a model of volume-overloaded heart hypertrophy. Hearts were taken after 1, 2, and 6 months postoperatively for immunohistochemical, histological and ultrastructural investigations. Immunohistochemical staining with some anti-extracellular matrix antibodies and ultrastructural findings allowed us to recognize intracardiocytic tunnels which were intracellular invaginations of plasmalemma surrounded by basement membrane. Inside the tunnels endothelial cells forming well-developed capillaries were entrapped. Tunnel capillary formation is discussed as an adaptive response to increased cardiac work due to volume overload.
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Supported in part by the funds of the Medical Academy of Warsaw
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Ratajska, A., Fiejka, E., Maksymowicz, M. et al. Tunnel capillaries in hypertrophied myocardium of rats with aorto-caval fistula. Basic Res Cardiol 88, 120–129 (1993). https://doi.org/10.1007/BF00798260
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DOI: https://doi.org/10.1007/BF00798260