Skip to main content
Log in

Ischemic preconditioning: a brief review

  • Focussed Issue: Ischemic Preconditioning
  • Ischemic Preconditioning: The Concept
  • Published:
Basic Research in Cardiology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Asimakis GK, Inners-McBride K, Medellin G, Conti VR (1992) Ischemic preconditioning attenuates acidosis and postischemic dysfunction in isolated rat heart. Am J Physiol 263: H887-H894

    Google Scholar 

  2. Bogoyevitch MA, Parker PJ, Sugden PH (1993) Characterization of protein kinase C isotype expression in adult rat heart. Protein kinase C-epsilon is a major isotype present, and it is activated by phorbol esters, epinephrine and endothelin. Circ Res 72: 757–767

    Google Scholar 

  3. Fleet WF, Johnson TA, Graebner CA, Gettes LS (1985) Effect of serial brief ischemic episodes on extracellular K+, pH, and activation in the pig. Circulation 72: 922–932

    Google Scholar 

  4. Hearse DJ (1995) Activation of ATP-sensitive potassium channels: A novel pharmacological approach to myocardial protection? (Review). Cardiovasc Res 30: 1–17

    Google Scholar 

  5. Kida M, Fujiwara H, Ishida M, Kawai C, Ohura M, Miura I, Yabuuchi Y (1991) Ischemic preconditioning preserves creatine phosphate and intracellular pH. Circulation 84: 2495–2503

    Google Scholar 

  6. Liu Y, Ytrehus K, Downey JM (1994) Evidence that translocation of protein kinase C is a key event during ischemic preconditioning of rabbit myocardium. J Mol Cell Cardiol 26: 661–668

    Google Scholar 

  7. Marber MS, Latchman DS, Walker JM, Yellon DM (1994) Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction. Circulation 1264: 1272

    Google Scholar 

  8. Marber M, Walker D, Yellon D (1994) Editorial. Ischaemic preconditioning. Br Med J 308: 1–2

    Google Scholar 

  9. Mitchell MB, Meng X, Ao L, Brown JM, Harken AH, Banerjee A (1995) Preconditioning of isolated rat heart is mediated by protein kinase C. Circ Res 76: 73–81

    Google Scholar 

  10. Murry CE, Jennings RB, Reimer KA (1986) Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium. Circulation 74: 1124–1136

    Google Scholar 

  11. Murry CE, Richard VJ, Reimer KA, Jennings RB (1990) Ischemic preconditioning slows energy metabolism and delays ultrastructural damage during a sustained ischemic episode. Circ Res 66: 913–931

    Google Scholar 

  12. Murry CE, Richard VJ, Jennings RB, Reimer KA (1991) Myocardial protection is lost before contractile function recovers from ischemic preconditioning. Am J Physiol (Heart Circ Physiol) 260: H796-H804

    Google Scholar 

  13. Nishizuka Y (1992) Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258: 607–614

    Google Scholar 

  14. Przyklenk K, Sussman MA, Simkhovich BZ, Kloner RA (1995) Does ischemic preconditioning trigger translocation of protein kinase C in the canine model? Circulation 92: 1546–1557

    Google Scholar 

  15. Reimer KA, Murry CE, Yamasawa I, Hill ML, Jennings RB (1986) Four brief periods of myocardial ischemia cause no cumulative ATP loss or necrosis. Am J Physiol 251: H1306-H1315

    Google Scholar 

  16. Speechly-Dick ME, Mocanu MM, Yellon DM (1994) Protein Kinase C: Its role in ischemic preconditioning in the rat. Circ Res 75: 586–590

    Google Scholar 

  17. Stable S, Parker PJ (1991) Protein kinase C. Pharmacol Ther 51: 71–95

    Google Scholar 

  18. Strasser RH, Braun-Dullaeus R, Walendzik H, Marquetant R (1992) 4-1 activation of protein kinase C in acute myocardial ischemia: Mechanisms for sensitization of the adenylyl cyclase system. Circ Res 70: 1304–1312

    Google Scholar 

  19. Tsuchida A, Liu Y, Liu GS, Cohen MV, Downey JM (1994) 4-2 agonists precondition rabbit ischemic myocardium independent of adenosine by direct activation of protein kinase C. Circ Res 75: 576–585

    Google Scholar 

  20. Vander Heide RS, Hill ML, Reimer KA, Jennings RB (1996) Effect of reversible ischemia on the activity of the mitochondrial ATPase: Relationship to ischemic preconditioning. J Mol Cell Cardiol (in press)

  21. Vander Heide RS, Schwartz LM, Jennings RB, Reimer KA (1995) Effect of catecholamine depletion on infarct size in dogs. Role of catecholamines in ischemic preconditioning. Cardiovasc Res 30: 656–667

    Google Scholar 

  22. Wolfe CL, Sievers RE, Visseren FL, Donnelly TJ (1993) Loss of myocardial protection after preconditioning correlates with the time course of glycogen recovery within the preconditioned segment. Circulation 87: 881–892

    Google Scholar 

  23. Yellon DM, Alkhulaifi AM, Pugsley WB (1993) Preconditioning the human myocardium. Lancet 342: 276–277

    Google Scholar 

  24. Ytrehus K, Liu Y, Downey JM (1994) Preconditioning protects ischemic rabbit heart by protein kinase C activation. Am J Physiol 266: H1145-H1152

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Reimer, K.A., Jennings, R.B. Ischemic preconditioning: a brief review. Basic Res Cardiol 91, 1–4 (1996). https://doi.org/10.1007/BF00788850

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00788850

Key words

Navigation