Summary
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1.
We have examined the effects of short-chain fatty acids on acetylcholine (ACh)-induced transmembrane currents using internally dialized neurons ofHelix.
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2.
Decenoic acid, which increased the fluidity of excitable membranes, caused dramatic changes in the voltage sensitivity of ACh currents consisting of an ACh-induced increase in membrane permeability for K+ and Na+ ions and a shift of theE rev of these ACh responses to more positive potentials. Valeric acid, which did not change the membrane fluidity, had no effect on this type of ACh response.
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3.
Changes of theE Na andE Cl had no effect on the size of the decenoic acid-induced shift of theE rev. But the influence of decenoic acid on the voltage sensitivity of ACh-induced currents almost disappeared after the change of theE K by the reduction of the internal K concentration.
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4.
Decenoic acid had no effect on ACh responses in which K+ ions were not involved in the generation of ACh-induced currents.
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5.
The results suggest that decenoic acid-induced changes in membrane fluidity modulate cholinoreceptive properties of the neuronal membrane by the inhibition of the K+ carrier involved in the generation of ACh responses.
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Arvanov, V.L., Takenaka, T., Dadalian, S.S. et al. The effects of short-chain fatty acids on the neuronal membrane functions ofHelix pomatia. II. cholinoreceptive properties. Cell Mol Neurobiol 6, 165–175 (1986). https://doi.org/10.1007/BF00711068
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DOI: https://doi.org/10.1007/BF00711068