Summary
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1.
The effects of short-chain fatty acids on the membrane excitability, currentvoltage (I-V) characteristics, and cell volume ofHelix pomatia neurons were studied.
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2.
2-Decenoic acid (DA), having 10 carbon atoms in the hydrocarbon chain, suppressed the excitability of bursting neurons RPal (Sakharov and Salanki, 1969) for 30–60 min, while valeric acid (VA), having 5 carbon atoms, had no significant effect on excitability.
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3.
DA had three different effects on the excitability of beating neurons: in some neurons DA suppressed excitability as in bursting neurons; in a second type of neuron DA had a negligible effect on excitability; and in the neuron located near RPa1 DA had a pentylentetrazol (PTZ)-like effect, i.e., it converted the discharge of the neuron from beating to bursting.
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4.
DA decreased the peak value of the current, inducing a negative-resistance region in theI-V curve of the bursting neuron without any change in the level of the voltage at which the current reaches its maximal value.
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5.
DA inhibited the hyperpolarization induced by activation of the Na+ pump, tested after preliminary enrichment of neurons with Na+ ions by incubation in a potassium-free solution for 20 min.
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6.
DA caused a swelling of the neuron by about 10% which was independent of the Na+ pump. In all the above-mentioned cases VA had no significant effect.
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Suleymanian, M.A., Takenaka, T., Stamboltsyan, K.V. et al. The effects of short-chain fatty acids on the neuronal membrane functions ofHelix pomatia. I. electrical properties. Cell Mol Neurobiol 6, 151–163 (1986). https://doi.org/10.1007/BF00711067
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DOI: https://doi.org/10.1007/BF00711067