Abstract
Stenothricin is a new antibiotic, which inhibits the cell wall synthesis of certain bacteria. It was isolated by partition chromatography, ion exchange chromatography, and gel filtration. The structural studies show, that stenothricin is a peptide antibiotic containing several uncommon amino acids, which could be identified by gas chromatography and mass spectrometry.
Zusammenfassung
Stenothricin ist ein neues Antibioticum, das die Zellwandsynthese verschiedener Bakterien hemmt. Es konnte mittels Verteilungs-Chromatographie, Ionenaustauscher-Chromatographie und Gelfiltration in reiner Form isoliert werden. Die Strukturuntersuchungen ergaben, daß es sich bei Stenothricin um ein Peptidantibioticum mit mehreren ungewöhnlichen Aminosäuren handelt, die durch Gas-Chromatographie und Massenspektrometrie identifiziert wurden.
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133. Mitteilung: Uchida, K., Wolf, H.: Inhibition of ribosomal peptidyl transferase bei hikizimycin, a nucleoside antibiotic. J. Antibiotics (in press, 1974).
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Hasenböhler, A., Kneifel, H., König, W.A. et al. Stoffwechselprodukte von Mikroorganismen. Arch. Microbiol. 99, 307–321 (1974). https://doi.org/10.1007/BF00696245
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DOI: https://doi.org/10.1007/BF00696245