Summary
We studied the effects of cyclosporin A and verapamil on the modulation of vincristine and daunorubicin resistance in a multidrug-resistant subline of human T-cell acute lymphatic leukemia GM3639. Our results show that cyclosporin A is more effective than verapamil as a modulator of the high degree of primary vincristine resistance and the low degree of daunorubicin cross-resistance expressed by this cell line. Isobologram analysis revealed that the combined modulators act synergistically in correcting both vincristine and daunorubicin resistance.
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Financially supported by the Marcia Slater Society for Research in Leukemia, the Jacob Wallerstein Foundation, and the Children's Leukemia Research Foundation
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Osann, K., Sweet, P. & Slater, L.M. Synergistic interaction of cyclosporin A and verapamil on vincristine and daunorubicin resistance in multidrug-resistant human leukemia cells in vitro. Cancer Chemother. Pharmacol. 30, 152–154 (1992). https://doi.org/10.1007/BF00686409
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DOI: https://doi.org/10.1007/BF00686409