Summary
Sustained-release theophylline 10.1 mg/kg b.d. was given with placebo or fenoterol 2.5 mg t.d.s. to 12 patients with chronic airway obstruction.
Fenoterol did not significantly affect the steady-state serum theophylline trough level (11.84 µg/ml for fenoterol vs 11.10 µg/ml for placebo). Addition of fenoterol produced no further increase in spirometric function nor in clinical status.
This is a preview of subscription content, log in via an institution to check access.
References
Wolfe JD, Tashkin DP, Calvarese B, Simmons M (1978) Bronchodilator effects of terbutaline and aminophylline alone and in combination in asthmatic patients. N Engl J Med 298: 363–367
Eggleston PA, Beasley PP, Kindley RT (1981) The effects of oral doses of theophylline and fenoterol on exercise-induced asthma. Chest 79: 399–405
Magnussen H, Jörres R, Hartmann V (1986) Bronchodilator effect of theophylline preparations and aerosol fenoterol in stable asthma. Chest 90: 722–725
Siegel D, Sheppard D, Gelb A, Weinberg P (1985) Aminophylline increases the toxicity but not the efficacy of an inhaled beta-adrenergic agonist in the treatment of acute exacerbations of asthma. Am Rev Respir Dis 132: 283–286
Shim CS, Williams MH (1983) Bronchodilator response to oral aminophylline and terbutaline versus aerosol albuterol in patients with chronic obstructive pulmonary disease. Am J Med 75: 697–701
Danziger Y, Garty M, Volwitz B, Ilfeld D, Varsano I, Rosenfeld JB (1985) Reduction of serum theophylline levels by terbutaline in children with asthma. Clin Pharmacol Ther 37: 469–471
Minette A (1970) Spirometric study of the bronchodilating effects of hydroxyphenylorciprenaline (Th 1165a) in various forms in a group of 124 coal miners suffering from bronchospasm. Respiration 27: 276–315
Burgess CD, Crane J, Graham AN, Maling TJB (1986) The hemodynamic effects of aminophylline and salbutamol alone and in combination. Clin Pharmacol Ther 40: 550–553
Filuk RB, Easton PA, Anthonisen NR (1985) Response to large doses of salbutamol and theophylline in patients with chronic obstructive pulmonary disease. Am Rev Respir Dis 132: 871–874
Billing B, Dahlqvist R, Hörnblad Y, Leideman T, Skareke L, Ripe E (1987) Theophylline in maintenance treatment of chronic asthma: concentration-dependent additional effect to beta2-agonist therapy. Eur J Respir Dis 70: 35–43
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lucena, M.I., Almagro, J., Rius, F. et al. Bronchodilator effect and serum theophylline level after combined treatment with fenoterol and theophylline in reversible chronic airflow obstruction. Eur J Clin Pharmacol 35, 669–671 (1988). https://doi.org/10.1007/BF00637605
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00637605