Abstract
To quantify fluid distribution at a moderate altitude (2,315 m) 29 male subjects were studied with respect to tissue thickness changes [front (forehead), sternum, tibia], changes of total body water, changes of plasma volume, total protein concentrations (TPC), colloid osmotic pressure (COP), and electrolytes. Tissue thickness at the forehead showed a significant increase from 4.14 mm to 4.41 mm 48 h after ascent to the Rudolfshuette (2,315 m) (P < 0.05). At 96 h after ascent the tissue thickness at the tibia was decreased to 1.33 mm compared to the control value of 1.59 mm (P < 0.01). Body mass increased from 75.5 kg (control) to 76.2 kg on the last day (P < 0.05) and body water from 44.21 to 45.01 during the week (P < 0.01). The accumulation fluid in the upper part of the body was paralleled by a decrease in TPC and COP. At 48 h after the ascent COP dropped from 29.5 mmHg to 27.5 mmHg (P < 0.01). After 96 h at moderate altitude COP was still significantly decreased compared to the control level. At 1.5 h after the return from the Rudolfshuette in Saalfelden (744m) COP was back to the control values. The TPC also showed an initial drop from 7.75 g · dl−1 to 7.48 g · dl−1 after 48 h at altitude and remained below the control value during the whole week (P < 0.01). It seems from our study that even with exposure to moderate altitude measurable fluid shifts to the upper part of the body occurred which were detected by our ultrasound method.
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References
Aukland K, Reed RK (1993) Interstitial-lymphatic mechanisms in the control of extracellular fluid volume. Physiol Rev 73:1–78
Bärtsch P. Pfluger N, Audétat M, Shaw S, Weidmann P, Vock P, Vetter W, Rennie D, Oelz O (1991) Effects of slow ascent to 5,559 m on fluid homeostasis. Aviat Space Environ Med 62:105–110
Bärtsch P, Shaw S, Weidmann P, Franciolli M, Maggiorini M, Oelz O (1992) Aldosterone, antidiuretic hormone, and atrial natriuretic peptide in acute mountain sickness. In: Sutton JR, Coates G, Houston CS (eds) Hypoxia and mountain medicine. Hypoxia Symposium 1991. Queen City Printers Inc., Burlington, vt., pp 73–81
Carson RP, Evans WO, Shields JL, Hannon JP (1969) Symptomatology, pathophysiology, and treatment of acute mountain sickness. Fed Proc 28:1085–1091
Claybaugh JR, Brooks DP, Cymerman A (1992) Hormonal control of fluid and electrolyte balance at high altitude in normal subjects. In: Sutton JR, Coates G, Houston CS (eds) Hypoxia and mountain medicine. Hypoxia Symposium 1991. Queen City Printer, Burlington, Vt., pp 61–72
Fulco CS, Cymerman A, Reeves JT, Rock PB, Trad LA, Young PM (1989) Propanolol and the compensatory circulatory responses to orthostasis at high altitude. Aviat Space Environ Med 60:1049–1055
Gunga HC, Baartz FJ, Herrenleben I, Kirsch K (1994) Fluid recruitment from shell tissues of the body during haemodialysis. Nephrol Dial Transplant 9:1288–1291
Guyton AC, Taylor A, Granger H (1975) Circulatory physiology. Dynamics and control of the body fluids. Saunders, Philadelphia
Hackett P, Rennie D (1976): The incidence, importance, and prophylaxis of acute mountain sickness. Lancet 11:1149–1155
Hackett P, Rennie D (1979) Acute mountain sickness. Lancet 1:491
Hackett P, Rennie D (1979) Rales, peripheral oedema, retinal hemorrhage and acute mountain sickness. Am J Med 67:214–218
Hannon JP, Chinn KSK, Shields JL (1969) Effects of acute high-altitude exposure on body fluids. Fed Proc 28:1178–1184
Hansen JM, Olsen NV, Feldt-Rasmussen B, Kanstrup I-L, Déchaux M, Dubray C, Richalet J-P (1994) Albuminuria and overall capillary permeability of albumin in acute altitude hypoxia. J Appl Physiol 76:1922–1927
Hayashi R, Seko A, Mitarai G (1988) Peripheral edema and retinal hemorrhage in Himalayan climbers. In: Ueda G, Kusama S, Voelkel NF (eds) High altitude medical science. Shinsu University, Matsumoto, pp 318–322
Kirsch K, Merke J, Hinghofer-Szalkay H, Barnkow M, Wicke HJ (1980a) A new miniature plethysmograph to measure volume changes in small circumscribed tissue areas. Pflügers Arch 383:189–194
Kirsch K, Merke J, Hinghofer-Szalkay H (1980b) Fluid distribution within superficial shell tissues along body axis during changes of body posture in man. Pflügers Arch 383:195–201
Kirsch K, Baartz FJ, Gunga HC, Röcker L (1993) Fluid shifts into and out of superficial tissues under microgravity and terrestrial conditions. Clin Investig 71: 687–689
Kryzwicki HJ, Consolazio CF, Johnson HL, Nielsen WC, Barnhart RA (1971) Water metabolism in humans during acute altitude exposure (4300 m). J Appl Physiol 30:806–809
Laurent TC (1987) Structure, function and turnover of the extracellular matrix. Adv Microcirc 13:15–34
Lobenhofer HP, Zink RA, Brendel W (1982) High altitude pulmonary oedema: analysis of 166 cases. In: Brendel W, Zink RA (eds) High altitude physiology and medicine. Springer, Berlin Heidelberg New York, pp 219–231
Rennie D, Frayser R, Gray G, Houston C (1972) Urine and plasma proteins in men at 5,400 m. J Appl Physiol 32: 369–373
Sachs L (1974) Angewandte Statistik, Planung und Auswertung, Methoden und Modell. Springer, Berlin Heidelberg New York
Strauss MB, Davis RK, Rosenbaum JD, Rossmeisl EC (1951) Water diuresis produced during recumbency by the intravenous infusion of isotonic saline solution. J Clin Invest 30: 862–868
Surks MI, Chinn KSK, Matoush LRO (1966) Alterations in body composition in man after acute exposure to high altitude. J Appl Physiol 21:1741–1756
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Gunga, H.C., Kirsch, K., Baartz, F. et al. Fluid distribution and tissue thickness changes in 29 men during 1 week at moderate altitude (2,315 m). Europ. J. Appl. Physiol. 70, 1–5 (1995). https://doi.org/10.1007/BF00601801
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DOI: https://doi.org/10.1007/BF00601801