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Electrophysiological and cognitive effects of lumbar myelography with iopamidol: comparison with diagnostic lumbar puncture

  • Diagnostic Neuroradiology
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Abstract

To assess the influence of contrast medium on cortical function, we studied 20 patients undergoing lumbar myelography with iopamidol and 10 patients undergoing diagnostic lumbar puncture (controls). The examinations performed before and 6 and 24 h after myelography (or lumbar puncture) included a neuropsychological battery and an electrophysiological evaluation. In the patients cranial CT was performed thrice to assess passage of contrast medium from the cerebrospinal fluid into the brain. Neither patients nor controls had significantly different scores on neuropsychological testing after the diagnostic examinations. A transient slowing of basal EEG activity could be detected in 2 patients and 3 controls 6 h after the lumbar puncture. In 3 patients CT showed a transient increase in density of the brain. None of the parameters studied was significantly affected by myelography with iopamidol. CT findings support the hypothesis of early clearance of iopamidol from brain tissue, explaining its low neurotoxicity.

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References

  1. Meador K, Hamilton WJ, El Gammal TAM, Demetropoulos KC, Nichols FT III (1984) Irreversible neurologic complication of metrizamide myelography. Neurology 34:817–821

    Article  CAS  PubMed  Google Scholar 

  2. Gelmers HJ (1979) Adverse side effects of metrizamide in myelography. Neuroradiology 18:119–123

    CAS  PubMed  Google Scholar 

  3. Paschalis C, Sotiriadou C, Siablis D, Papapetropoulos M (1985) Multiple adverse reactions following metrizamide myelography. J Neurol Neurosurg Psychiatry 48:338–340

    Article  Google Scholar 

  4. Yu YL, duBoulay GH, Paul E (1986) Influence of certain factors on the manifestations of the adverse effects of metrizamide myelography. Neuroradiology 28:339–343

    Article  CAS  PubMed  Google Scholar 

  5. Picard L, Vespignani H, Vieux-Rochat P, Moret CH, L'Espérance G, Montaut J, Weber M, Roland J (1979) Complications neurologiques graves des myélographies au métrizamide. J Neuroradiol 6:3–14

    CAS  PubMed  Google Scholar 

  6. Hauge O, Falkenberg H (1982) Neuropsychologic reactions and other side effects after metrizamide myelography. AJNR 3:229–232

    Google Scholar 

  7. Masdeu JC, Glista GG, Rubino FA, Martínez-Lage JM, Maravi E (1983) Transient motor aphasia following metrizamide myelography. AJNR 4:200–202

    CAS  PubMed  Google Scholar 

  8. Sarno JB (1985) Transient expressive (non fluent) dysphasia after metrizamide myelography. AJNR 6:945–947

    CAS  PubMed  Google Scholar 

  9. Angiari P, Crisi G, Merli GA (1984) Aphasia and right hemiplegia after cervical myelography with metrizamide. Neuroradiology 26:61–63

    Article  CAS  PubMed  Google Scholar 

  10. Schmidt RC (1980) Mental disorders after myelography with metrizamide and other water-soluble contrast media. Neuroradiology 19:153–157

    Article  CAS  PubMed  Google Scholar 

  11. Richert S, Sartor K, Holl B (1979) Subclinical organic psychosyndromes on intrathecal injection of metrizamide for lumbar myelography. Neuroradiology 18:177–184

    Article  CAS  PubMed  Google Scholar 

  12. Caillé JM, Guibert-Tranier F, Howa JM, Billerey J, Calabet A, Piton J (1980) Contamination encéphalique par la métrizamide après myélographie. J Neuroradiol 7:3–12

    PubMed  Google Scholar 

  13. Galle G, Huk W, Arnold K (1984) Psychopathometric demonstration and quantification of mental disturbances following myelography with metrizamide and iopamidol. Neuroradiology 26:229–233

    Article  CAS  PubMed  Google Scholar 

  14. Bendel CJA, Hoogland PH (1984) Quincke oedema following intrathecal administration of metrizamide. Neuroradiology 26: 415–416

    Article  CAS  PubMed  Google Scholar 

  15. Gelmers HJ (1984) Exacerbation of systemic lupus erythematosus, aspetic meningitis and acute mental symptoms following metrizamide lumbar myelography. Neuroradiology 26:65–66

    Article  CAS  PubMed  Google Scholar 

  16. Bannon KR, Braun IF, Pinto RS, Manuell M, Sudilovski A, Kricheff II (1983) Comparison of radiographic quality and adverse reactions in myelography with iopamidol and metrizamide. AJNR 4:312–313

    CAS  PubMed  Google Scholar 

  17. Turski PA, Sackett JF, Gentry LR, Strother CM, Matozzi F (1983) Clinical comparison of metrizamide and iopamidol for myelography. AJNR 4:309–311

    CAS  PubMed  Google Scholar 

  18. Hammer B (1980) Iopamidol, a new non-ionic hydrosoluble contrast media for neuroradiology. Neuroradiology 19:119–121

    Article  CAS  PubMed  Google Scholar 

  19. Latchaw RE, Hirsch WL, Horton JA, Bissonette D, Shaw WW (1985) Iohexol vs metrizamide: a study of efficacy and morbidity in cervical myelography. AJNR 6:931–933

    CAS  PubMed  Google Scholar 

  20. Brooks BS, El Gammal TAM, Van Tassel P, Stevenson TC (1985) C1−C2 myelography with iohexol and metrizamide: comparative study. AJNR 6:935–938

    CAS  PubMed  Google Scholar 

  21. Gebarski SS, Gabrielsen TO, Knake JE, Latack JT, Yang PJ, Hoff JT (1985) Iohexol vs metrizamide for cervical myelography. Double-blind trial. AJNR 6:923–926

    CAS  PubMed  Google Scholar 

  22. Eldevik OP, Nakstad P, Kendall BE, Hindmarsh T (1983) Iohexol in lumbar myelography: preliminary results from an open, non comparative multicenter clinical study. AJNR 4:299–301

    CAS  PubMed  Google Scholar 

  23. Skutta T, Vogelsang H, Galanski M, Hammer B, Weinmann HJ (1983) Clinical trial of iotrol for lumbar myelography. AJNR 4: 302–303

    CAS  PubMed  Google Scholar 

  24. Caillé JM, Gioux M, Arnè P, Paty J (1983) Neurotoxicity of nonionic iodinated water-soluble contrast media in myelography: experimental study.AJNR 4:1185–1189

    PubMed  Google Scholar 

  25. Nakstad P, Aaserud O, Helgetveit A, Nyberg-Hansen R, Ganes T, Bach-Gansmo T (1984) Cervical myelography with iohexol. Neuroradiology 26:123–129

    Article  CAS  PubMed  Google Scholar 

  26. Nakstad P, Helgetveit A, Aaserud O, Ganes T, Nyberg-Hansen R (1984) Iohexol compared to metrizamide in cervical and thoracic myelography. A randomized double blind parallel study. Neuroradiology 26:479–484

    Article  CAS  PubMed  Google Scholar 

  27. Ratcliff G, Sandler S, Latchaw R (1986) Cognitive and affective changes after myelography. A comparison of metrizamide and iohexol. AJNR 7:683–687

    Google Scholar 

  28. Kerber CW, Sovak M, Ranganathan RS,Heilman CB (1983) Iotrol, a new myelographic agent. 1. Radiography, CT, CSF clearance and brain penetration. AJNR 4:317–318

    CAS  PubMed  Google Scholar 

  29. Provinciali L, Signorino M, Giovagnoli AR, Baroni M, Angeleri F, Salvolini U, Pasquini U (1988) Lumbar myelography with iopamidol: a methodological approach to the investigation of side effects. Neuroradiology 30:528–533

    Article  CAS  PubMed  Google Scholar 

  30. Drory VE, Neufeld MY, Avrahamy E, Korczyn AD (1989) Serial EEG recordings following intrathecal metrizamide administration. Clin Electroencephalogr 20:202–208

    Article  CAS  PubMed  Google Scholar 

  31. Floras P, Deliac P, Gross C, Jouet P, Paty J, Caillé JM (1990) Neurotoxicity of iohexol vs iopamidol in lumbar myelography. Clinical, electrophysiological and brain CT scan correlations.J Neuroradiol 17:190–200

    CAS  PubMed  Google Scholar 

  32. Olsen NK, Madsen HH, Eriksen FB, Svare U, Zeeberg I (1990) Intracranial iohexol distribution following cervical myelography, postmyelographic registration of adverse effects, psychometric assessment and electroencephalographic recording. Acta Neurol Scand 82:321–328

    Article  CAS  PubMed  Google Scholar 

  33. Sand T, Stonner LJ, Dale L, Salvesen R (1987) Side effects after diagnostic lumbar puncture and lumbar iohexol myelography. Neuroradiology 29:385–388

    Article  CAS  PubMed  Google Scholar 

  34. Cooney GA, Epstein CM (1984) EEG frequency analysis in metrizamide radiography. Neurology 34:1102–1105

    Article  CAS  PubMed  Google Scholar 

  35. Duchin KL, Drayer BP, Ross M, Allen S, Frantz M (1986) Pharmacokinetics of iopamidol after intrathecal administration in humans. AJNR 7:895–898

    CAS  PubMed  Google Scholar 

  36. Greitz T, Hindmarsh T (1974) Computer assisted tomography of intracranial CSF circulation using a water-soluble contrast medium. Acta Radiol 15:497–507

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Istituto Malattie del Sistema Nervoso, Università degli Studi di Ancona, Ancona, Italy

    L. Provinciali, M. G. Ceravolo, M. Signorino & M. Baroni

  2. Servizio di Neuroradiologia, Osp. Gen. Reg. Torrette, Ancona, Italy

    U. Pasquini & U. Salvolini

  3. Bracco, Milan, Italy

    R. Cerrutti

Authors
  1. L. Provinciali
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  2. M. G. Ceravolo
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  3. M. Signorino
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  4. M. Baroni
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  5. U. Pasquini
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  6. R. Cerrutti
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  7. U. Salvolini
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Provinciali, L., Ceravolo, M.G., Signorino, M. et al. Electrophysiological and cognitive effects of lumbar myelography with iopamidol: comparison with diagnostic lumbar puncture. Neuroradiology 35, 483–486 (1993). https://doi.org/10.1007/BF00588700

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  • DOI: https://doi.org/10.1007/BF00588700

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