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Distribution and antitumoral activity of adriamycin combined with warfarin in mice

  • Original Articles
  • Adriamycin, Warfarin, Pharmacology
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Summary

The distribution of adriamycin (AM) in C57Bl/6 mice bearing intramuscular Lewis lung carcinoma under the influence of combined treatment with warfarin (W) was investigated by a fluorimetric procedure. AM was injected IV at the dose of 7.5 mg/kg 14 days after tumor transplantation and W was given in the drinking water for 96 h, starting 24 h before AM. No substantial modifications in the serum and tissue distribution of AM fluorescence were observed under combined short-term treatment with W.

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Authors and Affiliations

  1. Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I-20157, Milan, Italy

    Paola Ghersa & Maria Grazia Donelli

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  1. Paola Ghersa
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  2. Maria Grazia Donelli
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Ghersa, P., Donelli, M.G. Distribution and antitumoral activity of adriamycin combined with warfarin in mice. Cancer Chemother. Pharmacol. 5, 43–47 (1980). https://doi.org/10.1007/BF00578561

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  • DOI: https://doi.org/10.1007/BF00578561

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